I got sick after cooking and eating dinner for friends. They got sick too. Another friend was there, who didn't eat. They didn't get sick. Was it something in the food ? Was it something I picked up and passed on through cooking ? ( I had been up to Tahoe skiing a week or two or so prior. Oh and almost forgot. Person at work(small office) sick and couple others w/family members sick)
There is absolutely no way I can believe there isn't some type of infectious agent-- either as trigger of another dormant agent or in and of itself. Whether or not that agent kicks in some long term type auto immune response I don't know. Or effects signaling per your post. Or
There is also the theory that infectious agent lives in B cells. The delay ? Lots to kill off and system to turn around and be in "normal" functional mode again.
< giant sigh> It's all a mystery. At this point, I care less and less about the what and why. Only how. How to get better -- to any significant degree. Of course, that's been the point all along........... so many many many freaking years.
ETA apologies
dsdmom for getting away from your original question.
I wanted to just add that maybe going and looking at the other protocols and the prophylactics used ( like the ongoing benadryl dosing) might help you with your side effects...... If they are somehow from the drug or reaction to the drug. ( even if it is a response specific to the med only w/ ME/CFS ) Something to ask your treating physician.