I stumbled across this study last night and found this somewhat concerning:
"Research has focused on glycation by glucose, assumed to be the most relevant sugar in both non-pathological tissues and hyperglycaemic conditions. However, glucose is not an efficient glycating agent as it overwhelmingly adopts its thermodynamically stable pyranose form, rather than the reactive open-chain aldehyde form.
Pentoses such as ribose and especially R5P (ribose-5-phosphate) are much more potent glycating agents, R5P reacting with amines 150-fold faster than glucose [4,5]. R5P and the mechanistically almost indistinguishable ADPR (adenosine diphosphate ribose) are both released into the extra-cellular matrix on cell necrosis, so are present in chronic inflammation where there is long-term cellular damage, and so could be potent biologically significant and, to date, under-investigated glycating agents."
This is based on preliminary in vitro work, but just wondering if one is should be concerned if they're taking decent amounts of riboflavin, d-ribose, or R5P (the active form of riboflavin) and have glycation, inflammation or blood sugar issues?
"Research has focused on glycation by glucose, assumed to be the most relevant sugar in both non-pathological tissues and hyperglycaemic conditions. However, glucose is not an efficient glycating agent as it overwhelmingly adopts its thermodynamically stable pyranose form, rather than the reactive open-chain aldehyde form.
Pentoses such as ribose and especially R5P (ribose-5-phosphate) are much more potent glycating agents, R5P reacting with amines 150-fold faster than glucose [4,5]. R5P and the mechanistically almost indistinguishable ADPR (adenosine diphosphate ribose) are both released into the extra-cellular matrix on cell necrosis, so are present in chronic inflammation where there is long-term cellular damage, and so could be potent biologically significant and, to date, under-investigated glycating agents."
This is based on preliminary in vitro work, but just wondering if one is should be concerned if they're taking decent amounts of riboflavin, d-ribose, or R5P (the active form of riboflavin) and have glycation, inflammation or blood sugar issues?