Tom Kindlon posted this to co-cure Feb 9 2010
[Tom: This study used the "empiric criteria" (Reeves, 2005) for CFS]
(if: Am I missing something? Is this Reeves doing biomedical research? Is there something wrong here? What, if any, are the implications?)
Chronic fatigue syndrome is associated with metabolic syndrome: results from
a case-control study in Georgia
Maloney EM, Boneva RS, Lin JM, Reeves WC.
Metabolism. 2010 Jan 25. [Epub ahead of print]
Centers for Disease Control and Prevention, Chronic Viral Diseases Branch,
National Center for Zoonotic, Vector-borne and Enteric Diseases, MS-A15,
1600 Clifton Rd, Atlanta, GA 30333, USA.
We hypothesized that persons with chronic fatigue syndrome (CFS) would have
a higher prevalence of metabolic syndrome compared with well controls, and
that unwell persons with insufficient symptoms or fatigue for CFS (termed
ISF) would have a prevalence of metabolic syndrome intermediate between
those with CFS and the controls.
We also sought to examine the relationship
between metabolic syndrome and measures of functional impairment, fatigue,
and other symptoms.
Our analysis was based on a population-based
case-control study conducted in metropolitan, urban, and rural areas of
Georgia, United States, between September 2004 and July 2005. There were 111
persons with CFS, 259 with ISF, and 123 controls.
Metabolic syndrome was
determined based on having at least 3 of 5 standard risk components
(abdominal obesity, high triglycerides, high blood pressure, elevated
fasting glucose, and decreased high-density lipids) according to the
National Cholesterol Education Program Adult Treatment Panel III definition.
Persons with CFS were 2-fold as likely to have metabolic syndrome (odds
ratio = 2.12, confidence interval = 1.06, 4.23) compared with the controls.
There was a significant graded relationship between the number of metabolic
syndrome factors and CFS; each additional factor was associated with a 37%
increase in likelihood of having CFS. The association of ISF with metabolic
syndrome was weaker (odds ratio = 1.72, confidence interval = 0.94-3.16).
Among persons with CFS, the number of metabolic syndrome factors was
significantly correlated with worse fatigue on a standardized summary
measure of fatigue (r = 0.20, P = .04).
In conclusion, CFS was associated
with metabolic syndrome, which further exacerbated fatigue.
Published by Elsevier Inc.
PMID: 20102774 [PubMed - as supplied by publisher]
From Wiki:
[Tom: This study used the "empiric criteria" (Reeves, 2005) for CFS]
(if: Am I missing something? Is this Reeves doing biomedical research? Is there something wrong here? What, if any, are the implications?)
Chronic fatigue syndrome is associated with metabolic syndrome: results from
a case-control study in Georgia
Maloney EM, Boneva RS, Lin JM, Reeves WC.
Metabolism. 2010 Jan 25. [Epub ahead of print]
Centers for Disease Control and Prevention, Chronic Viral Diseases Branch,
National Center for Zoonotic, Vector-borne and Enteric Diseases, MS-A15,
1600 Clifton Rd, Atlanta, GA 30333, USA.
We hypothesized that persons with chronic fatigue syndrome (CFS) would have
a higher prevalence of metabolic syndrome compared with well controls, and
that unwell persons with insufficient symptoms or fatigue for CFS (termed
ISF) would have a prevalence of metabolic syndrome intermediate between
those with CFS and the controls.
We also sought to examine the relationship
between metabolic syndrome and measures of functional impairment, fatigue,
and other symptoms.
Our analysis was based on a population-based
case-control study conducted in metropolitan, urban, and rural areas of
Georgia, United States, between September 2004 and July 2005. There were 111
persons with CFS, 259 with ISF, and 123 controls.
Metabolic syndrome was
determined based on having at least 3 of 5 standard risk components
(abdominal obesity, high triglycerides, high blood pressure, elevated
fasting glucose, and decreased high-density lipids) according to the
National Cholesterol Education Program Adult Treatment Panel III definition.
Persons with CFS were 2-fold as likely to have metabolic syndrome (odds
ratio = 2.12, confidence interval = 1.06, 4.23) compared with the controls.
There was a significant graded relationship between the number of metabolic
syndrome factors and CFS; each additional factor was associated with a 37%
increase in likelihood of having CFS. The association of ISF with metabolic
syndrome was weaker (odds ratio = 1.72, confidence interval = 0.94-3.16).
Among persons with CFS, the number of metabolic syndrome factors was
significantly correlated with worse fatigue on a standardized summary
measure of fatigue (r = 0.20, P = .04).
In conclusion, CFS was associated
with metabolic syndrome, which further exacerbated fatigue.
Published by Elsevier Inc.
PMID: 20102774 [PubMed - as supplied by publisher]
From Wiki:
Metabolic syndrome is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes.[1] It affects one in five people, and prevalence increases with age. Some studies estimate the prevalence in the USA to be up to 25% of the population.[2]
Metabolic syndrome is also known as metabolic syndrome X, syndrome X, insulin resistance syndrome, Reaven's syndrome, and CHAOS (Australia)[3]. A similar condition in overweight horses is referred to as equine metabolic syndrome; it is unknown if they have the same etiology.
Metabolic syndrome is also known as metabolic syndrome X, syndrome X, insulin resistance syndrome, Reaven's syndrome, and CHAOS (Australia)[3]. A similar condition in overweight horses is referred to as equine metabolic syndrome; it is unknown if they have the same etiology.