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Read this before trying choline.

linusbert

Senior Member
Messages
1,396
My results came in: my Nitro-Tyrosine was 626 nmol/L where the laboratory upper limit was 630 nmol/L. Since on the day of the blood draw my allergies were not that bad and the measured level was right at the upper limit, I am inclined to believe it is related to my chemical allergies. It is quite possible that, on my worse days, the nitro-tyrosine would be over the upper limit, so I will definitely keep on eye on this blood marker in the future in spite of the high cost for the test.
i really would go for a round of hydroxocobalamin 500-1000ug or even above.
nitro tyrosine is a marker for nitro radical stress. HYDROXOcobalamin is basically like a direct detox to that kind of ROS as it binds with NO and prevents the excessive formation.
therefore it does not fix the root problem (if the root problem isnt a b12 deficiency) but it can help prevent further damage to your body.

Choline's main effect is on the liver.
The liver is where meds are metabolized.

I wonder what the effect that choline can have on the liver that worsens a condition.

Let me think about this.
has big effects on the liver, beyond that its important in the methylation pathways as methylgroup donor. and also acetylation as acetylcholin later.
 
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cristi_b

Senior Member
Messages
103
i really would go for a round of hydroxocobalamin 500-1000ug or even above.
nitro tyrosine is a marker for nitro radical stress. HYDROXOcobalamin is basically like a direct detox to that kind of ROS as it binds with NO and prevents the excessive formation.
therefore it does not fix the root problem (if the root problem isnt a b12 deficiency) but it can help prevent further damage to your body.
My vitamin B12 was measured at 676 pg/mL which is above average, I also eat a lot of meat so there's no chance of developing a deficiency. I've tried hydroxocobalamin and it causes sympathetic activation: I sleep less and become very irritable so unfortunately I cannot take it. Since NO has antimicrobial properties I tend to believe that there's some pathogen somewhere and my body is producing excess amounts to handle the infection.
 

linusbert

Senior Member
Messages
1,396
My vitamin B12 was measured at 676 pg/mL which is above average, I also eat a lot of meat so there's no chance of developing a deficiency. I've tried hydroxocobalamin and it causes sympathetic activation: I sleep less and become very irritable so unfortunately I cannot take it. Since NO has antimicrobial properties I tend to believe that there's some pathogen somewhere and my body is producing excess amounts to handle the infection.
its not so much about a b12 deficieny , its therapeutical use of a vitamin. you use the NO binding properties. too much can create a very dangerous ROS species. which wreaks havoc in the body. but of course you get the side effects of a high dose vitamin like imbalances and stuff. which is sad.
but 700 seams like a good enough level. i guess the body is able t oconvert to hydroxocobalamin if in need.
 
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