mariovitali
Senior Member
- Messages
- 1,214
I am posting some thoughts here because i did not want to derail the original thread :
https://forums.phoenixrising.me/ind...eatment-by-victoria-bohne-in-norwegian.44871/
cc : @Frenchguy @Janet Dafoe (Rose49) @Hip @perrier @JES @pattismith
Regarding the patent itself : I do not understand how one is able to practically patent a mixture of compounds that can be easily found by anyone. In order to patent something you must explicitly state the ingredients and the exact composition that comprises the solution. If you do this with easy-to find ingredients then anyone can just follow the instructions and prepare the solution for themselves.
Moving on now to the ingredients comprising the patent : I saw Spinach being mentioned and also ALA, Thiamine, Biotin, Niacin.
My understanding is that the inventors are using Oxalates to inhibit Lactate Dehydrogenase :
As discussed, Liver Disease can be a potential reason for increased lactate levels :
Source : https://www.semanticscholar.org/pap...nson/b9ab0b17a45c1f2e1b65b0c8417392a6045a28b6
The use of Spinach deserves a closer look : Spinach is not only loaded with Oxalates, but is also rich in Vitamin K (100 g = 460% RDA) and a substance called Dolichol.
Here is a snapshot from a user called "Trynottoworry" who first speaks about the Unfolded Protein Response, N-Linked Glycosylation back in 2011 and talks about "The Spinach" Diet. Source is from a forum called propeciahelp.com, a site for people who took Finasteride and ended up with "Post-Finasteride Syndrome" a syndrome with several overlaping symptoms as with ME/CFS :
Note also the mention of a gene called GPT :
The inventors state that their patent may be useful for Liver Disease. I previously discussed that Spinach contains Vitamin K and also Dolichol.
Interestingly, a soilution called Ropren (which i tried) uses a patented solution to treat Liver Disease and Chronic Hepatitis ;
Source : http://www.solagran.com/ropren.html
I have previously expressed my concerns for Niacin for people with Liver Disease. Vitamin K metabolism has been discussed (see discussion here) as an important component on the treatment of ME/CFS (hypothesis) and has been communicated to both Professor Ron Davis and Dr Phair.
https://forums.phoenixrising.me/ind...eatment-by-victoria-bohne-in-norwegian.44871/
cc : @Frenchguy @Janet Dafoe (Rose49) @Hip @perrier @JES @pattismith
Regarding the patent itself : I do not understand how one is able to practically patent a mixture of compounds that can be easily found by anyone. In order to patent something you must explicitly state the ingredients and the exact composition that comprises the solution. If you do this with easy-to find ingredients then anyone can just follow the instructions and prepare the solution for themselves.
Moving on now to the ingredients comprising the patent : I saw Spinach being mentioned and also ALA, Thiamine, Biotin, Niacin.
My understanding is that the inventors are using Oxalates to inhibit Lactate Dehydrogenase :
The conjugate base of oxalic acid is the hydrogenoxalate anion, and its conjugate base (oxalate) is a competitive inhibitor of the lactate dehydrogenase (LDH) enzyme.[26]LDH catalyses the conversion of pyruvate to lactic acid (end product of the fermentation (anaerobic) process) oxidising the coenzyme NADH to NAD+ and H+ concurrently. Restoring NAD+ levels is essential to the continuation of anaerobic energy metabolism through glycolysis. As cancer cells preferentially use anaerobic metabolism (see Warburg effect) inhibition of LDH has been shown to inhibit tumor formation and growth,[27] thus is an interesting potential course of cancer treatment.
As discussed, Liver Disease can be a potential reason for increased lactate levels :
The serum lactate dehydrogenase (LDH) of 16 normal subjects was inhibited by 55 to 68% by the incorporation into the reaction mixture of 0.2 mM-oxalate. Oxalate inhibited the serum LDH of 17 out of 19 patients with myocardial infarction to a greater extent, and that of 16 out of 18 patients with liver disease to a lesser extent than that of the controls. The serum LDH of all 16 patients with liver disease was inhibited by 2 M-urea to a greater degree and that of eight out of nine patients with myocardial infarction to a lesser extent than that of the normal controls (45-62%).
Source : https://www.semanticscholar.org/pap...nson/b9ab0b17a45c1f2e1b65b0c8417392a6045a28b6
The use of Spinach deserves a closer look : Spinach is not only loaded with Oxalates, but is also rich in Vitamin K (100 g = 460% RDA) and a substance called Dolichol.
Here is a snapshot from a user called "Trynottoworry" who first speaks about the Unfolded Protein Response, N-Linked Glycosylation back in 2011 and talks about "The Spinach" Diet. Source is from a forum called propeciahelp.com, a site for people who took Finasteride and ended up with "Post-Finasteride Syndrome" a syndrome with several overlaping symptoms as with ME/CFS :
Note also the mention of a gene called GPT :
- This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
The inventors state that their patent may be useful for Liver Disease. I previously discussed that Spinach contains Vitamin K and also Dolichol.
Interestingly, a soilution called Ropren (which i tried) uses a patented solution to treat Liver Disease and Chronic Hepatitis ;
In 2007, Ropren (Bioeffective ® R) was approved by the Russian Ministry of Health for entry into the Russian Pharmacopoeia as a hepatoprotector for use in treating chronic hepatitis and hepatobiliary dysfunction - with monographs for both the active raw material (“Ropren® substance”) and the finished product (“Ropren® drops”), a solution of Bioeffective® R in a pharmaceutical grade oil.
<SNIP>
These polyprenols are naturally occurring analogues and precursors of dolichol, and play an important role in all vital functions and are essential in cellular biosynthesis of glycopeptides (glycoproteins).
Source : http://www.solagran.com/ropren.html
I have previously expressed my concerns for Niacin for people with Liver Disease. Vitamin K metabolism has been discussed (see discussion here) as an important component on the treatment of ME/CFS (hypothesis) and has been communicated to both Professor Ron Davis and Dr Phair.
Last edited: