Rapid improvement in severe long COVID following perispinal etanercept July 6, 2022

[keepontruckin]

https://www.tandfonline.com/doi/abs/10.1080/03007995.2022.2096351

Etanercept is the biologic Dr. Nancy Klimas used in her Gulf War research that she was going to try in me cfs. It is a biologic used for serious autoimmune disease I think.

This study aimed to describe the neurological improvements in a patient with severe long COVID brain dysfunction following perispinal etanercept administration. Perispinal administration of etanercept, a novel method designed to enhance its brain delivery via carriage in the cerebrospinal venous system, has previously been shown to reduce chronic neurological dysfunction after stroke. Etanercept is a recombinant biologic that is capable of ameliorating two components of neuroinflammation: microglial activation and the excess bioactivity of tumor necrosis factor (TNF), a proinflammatory cytokine that is a key neuromodulator in the brain. Optimal synaptic and brain network function require physiological levels of TNF. Neuroinflammation, including brain microglial activation and excess central TNF, can be a consequence of stroke or peripheral infection, including infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19.

 

[godlovesatrier]

Does it cost an absolute fortune? As it's a biologic I assume it does.

 

[Pyrrhus]

Related discussion:

Anti-inflammatories may reduce symptoms in the short-term, but may not in the long-term
https://forums.phoenixrising.me/thr...hort-term-but-may-not-in-the-long-term.80492/

 

[keepontruckin]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

 

[Judee]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

Can you explain?

(It's okay if you can't. I mostly get the gist of all things scientific so understand when others are the same. No pressure. )

 

[Pyrrhus]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

By the way, the most potent anti-inflammatories all happen to be biologics...

 

[keepontruckin]

Well I learned something new. Are you aware of any biologics that have helped me cfs?

 

[Pyrrhus]

Well I learned something new. Are you aware of any biologics that have helped me cfs?

Hmm. Well, Ampligen is a biologic...

 

[MonkeyMan]

Cort has a nice write-up on this and other treatments here, and here's a quote from the scientific article:

“Perispinal etanercept is a promising treatment for the chronic neurologic dysfunction that may persist after resolution of acute COVID-19, including chronic cognitive dysfunction, fatigue, and depression. These results suggest that long COVID brain neuroinflammation is a potentially reversible pathology and viable treatment target. In view of the increasing unmet medical need, clinical trials of perispinal etanercept for long COVID are urgently necessary.”