Rapid improvement in severe long COVID following perispinal etanercept July 6, 2022

[keepontruckin]

https://www.tandfonline.com/doi/abs/10.1080/03007995.2022.2096351

Etanercept is the biologic Dr. Nancy Klimas used in her Gulf War research that she was going to try in me cfs. It is a biologic used for serious autoimmune disease I think.

This study aimed to describe the neurological improvements in a patient with severe long COVID brain dysfunction following perispinal etanercept administration. Perispinal administration of etanercept, a novel method designed to enhance its brain delivery via carriage in the cerebrospinal venous system, has previously been shown to reduce chronic neurological dysfunction after stroke. Etanercept is a recombinant biologic that is capable of ameliorating two components of neuroinflammation: microglial activation and the excess bioactivity of tumor necrosis factor (TNF), a proinflammatory cytokine that is a key neuromodulator in the brain. Optimal synaptic and brain network function require physiological levels of TNF. Neuroinflammation, including brain microglial activation and excess central TNF, can be a consequence of stroke or peripheral infection, including infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19.

 

[godlovesatrier]

Does it cost an absolute fortune? As it's a biologic I assume it does.

 

[Pyrrhus]

Related discussion:

Anti-inflammatories may reduce symptoms in the short-term, but may not in the long-term
https://forums.phoenixrising.me/thr...hort-term-but-may-not-in-the-long-term.80492/

 

[keepontruckin]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

 

[Judee]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

Can you explain?

(It's okay if you can't. I mostly get the gist of all things scientific so understand when others are the same. No pressure. )

 

[Pyrrhus]

I thought biologics were not anti inflammatories in the usual way we think of anti inflammatories.

By the way, the most potent anti-inflammatories all happen to be biologics...

 

[keepontruckin]

Well I learned something new. Are you aware of any biologics that have helped me cfs?

 

[Pyrrhus]

Well I learned something new. Are you aware of any biologics that have helped me cfs?

Hmm. Well, Ampligen is a biologic...

 

[MonkeyMan]

Cort has a nice write-up on this and other treatments here, and here's a quote from the scientific article:

“Perispinal etanercept is a promising treatment for the chronic neurologic dysfunction that may persist after resolution of acute COVID-19, including chronic cognitive dysfunction, fatigue, and depression. These results suggest that long COVID brain neuroinflammation is a potentially reversible pathology and viable treatment target. In view of the increasing unmet medical need, clinical trials of perispinal etanercept for long COVID are urgently necessary.”

 

[SWAlexander]

Ampligen

also known as Rintatolimod is very expensive.
According to Wikipedia: "Although Ampligen was initially cleared for use in Canada in 1997, and obtained orphan drug status for treatment of CFS in the European Union in 2000, it is approved for use only in Argentina."
However: Therapeutic medicines against coronavirus infection Covid-19 https://www.vfa.de/de/englische-inh...s-coronavirus-covid-19#antivirale-medikamente