percyval577
nucleus caudatus et al
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I searched then and found this sentence (page 7):Yes. Unfortunately it was a very small study, though, with apparently only 5 patients and 5 controls (as suggested by Figure 1).
Why would they "focus" on those ones?? So, they cheated a bit, and dropped the ones with allergies. Maybe they did some other study at the same time, and here the ones with allergies might have displayed any significance??The selection of subjects
for inclusion into the gene expression pilot study,
focused on those without allergies, to whom an exercise challenge was given:
5 women with CFS and 5 female controls.
In some sense well, nothing really conclusive for ME/CFS. It´s only that the suggested symptoms - which are by far not restricted to ME/CFS - have been found to have ion channels problems involved (I think this will be really sure enough).Do you mean that the ICC Committee made up the "ion transport issues" as part of the criteria so it would have more weight (but there was nothing to back it up)? What would be the purpose of doing that?
This is the Review @Mary found linked in her second quote from the ME-pedia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935107/pdf/kjped-57-1.pdf 2014
I havn´t already read this very interesting looking article (but it seems that they even wouldn´t mention ME/CFS).
In the ICC from 2012 (here the primer for medical practitioners: Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf)
one should find back some of the 2014 reviewed literature.
The question is, I think: What does it say that these symptoms have been found to have involved an ion channel problem? Is it a cause, or technical follow up from whatever? Do other diseases for sure not involve an ion channel problem? How are these more or less well known symptoms related to ME/CFS in its wholeness?
I really think they only made a quite narrow definition using/making an observation that patients who presumably suffer from this not-understood illness often display these widespread symptoms as well (saying "look, here are ion channel problems"); there is no special/important hint why ion transport issues (and in these special diseases/symptoms) would be an essential part of the ME/CFS (if at all).
My temperature is generally low, especially in the extremities (only sometimes, though very seldom, it suddenly is normal). Then I have very seldom some asthma, but more regularly difficulties to breathe in a halfway comfortable manner. Honestly, I don´t know how my strange heartbeat would fit in. So, the last points are only occasionally, and the first point is occasionally absent.How do you know that you occasionally meet criteria for an ion transport issue? Do you mean an autoantibody or a genetic issue (or something else)? Also, you did not have muscle weakness or fatiguability unless it was triggered by certain combinations of foods?
I put my words not exactly, however, b/c of this occasionality, you might exclude me from the ICC. But reading through the forum, I am not sure if this would be a justified idea.
My muscle pain only arose from having drunken beer (0.9l) and then ca. 4-22 h later eating cheese or other calcium rich food. I have read that patients from the EBV subgroup would tend to suffer with leg pain, and this I have (it´s slowly vanishing, but has been very uncomfortable). Though I have not read that they especially would not suffer fro muscle pain.
Recently I had muscle aches obviously from tea, when I had started drinking tea again, after having discovered that I can drink tea without feeling worse and heavy if I only drink a sip of vitamin D before a sip of tea (and b/c I love tea, I obviously overdid it). Tea might be bad b/c of some manganese, and/or it´s influence on the thyroid (infomation from @PatJ).
When I detoriated, I had for a week a weakness in movements that tried to lift up things, it never came back so far. I generally can feel quite sluggish, but I could also ride bike a whole day. Movements had never disturbed me mentally, but now while improving (feeling rather good now) this happens quite soon and lasts for some hours (... and potentially for more).
I remember this also, I think also non-voltage gated ones, NMDAR´s(?)That is my understanding @Inara (that Mg ions can block the voltage gated calcium channels which are already blocked for me by an autoantibody). This is as deep as my understanding goes though and I cannot tell you anything more!
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