This question is for all the methylation experts out there and I am flagging the people that my foggy brain can remember @
Freddd @
Valentijn @
caledonia.
I just found out I have both MTHFR mutations (I think it is called compound heterozygous) and I will be starting on Methyl B-12 shots 3x/wk and 5-MTHF supplements. Both just ordered and I should have them next week.
My question is this, I read somewhere on PR that there are certain supplement(s) that PWC's have taken that increased their success at tolerating the methylation supplements. I did a site search but couldn't remember or find what I was looking for.
Can someone remind me, is it potassium or niacin or something else that many have taken along with the methylation supplements? I appreciate any advice and as always, thank you guys in advance.
Hi Gingergrrl,
Often on around the third day after methylation starts, which normally causes a brightening of the senses as a result of dimming being a result of deficiency, people have sudden increases of some symptoms that usually come down to low serum potassium and/or a donut hole paradoxical folate deficiency (partial methylation block by triage level) and can be corrected. It is important to do so with the potassium as that can cause dangerous and even fatal consequences. And healing increases as the folate deficiency symptoms are decreased.
The sensory brightening, increased need for methylfolate and increased need for potassium are all flags of cell formation and healing. Follow the clues towards healing. They will likely seem counter intuitive. Neurological healing can be unpleasant at some stages and a lot of work. Everything can hurt more and differently. That also provide clues to healing when you can see all your separate pains and so on.
After you get things balanced out after that initial balancing period adding AdoCbl sublingually and L-carnitine fumarate, you will take care of the entire Deadlock Quartet and maybe be able to get all levels healing.
Here are many of the typical induced deficiency at startup, and continuing with some fluctuations.
Version 1.2 12/08/2013
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).
There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.
IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,
Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness
Abnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressure
Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.
Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.
Old symptoms returning
Edema
Angular Cheilitis, Canker sores,
Skin rashes, increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips,
Increased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,
Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Increase irritability, Heart palpitations,
Longer term, very serious
Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily
Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
