• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Pyridoxine-Plus (vs p5p)

Messages
34
Hello!

I'm doing this mineral balancing protocol from the company Trace Elements Inc. Part of the protocol involves large doses of B6. They recommend I take ~110mg daily, 109mg of which is in the inactive, Pyridoxine form, the other milligram is in the p5p active form.

Do any of you know what the rationale behind this is? Why would the company be using such a high dose of inactive b6 when it is linked to neuropathy and nerve damage? I am wondering if they added the milligram of p5p to somehow stimulate the body to convert the rest, because I can't understand why they wouldn't just use the active form.

Thanks.
 
Messages
34
Because its cheaper and they're speculating only a small percentage of the population can't convert pyridoxine into P-5-P? Or get neuropathy at such a dose.
Thanks for the response. So does p5p cause neuropathy at high doses just like pyridoxine? I thought nerve damage was only proven to happen with regular b6?
 

pamojja

Senior Member
Messages
2,398
Location
Austria
From what I've read on the internet the last 12 year, only pyridoxine might cause neuropathy, more likely above 500 mg/d. Never heard p5p could cause it too.

In my case took pyridoxine at about 80 mg addtional to an equal amount of p5p daily. Last year the EU must have outruled anything B6 above 20 mg per dose. Since I had surplus pyridoxine and run low on p5p, I increased pyridoxine to about 120 mg. Only than, after taking pyridoxine at above noted dose for 10 years without any problem, did neuropathy problems start this spring, couriously in my left arm only.

Reduced the pyridoxine again, and found a new source of p5p in Europe. By taking 6x 20mg doses each day, the neuropathy gradually decreased again.
 
Messages
34
From what I've read on the internet the last 12 year, only pyridoxine might cause neuropathy, more likely above 500 mg/d. Never heard p5p could cause it too.

In my case took pyridoxine at about 80 mg addtional to an equal amount of p5p daily. Last year the EU must have outruled anything B6 above 20 mg per dose. Since I had surplus pyridoxine and run low on p5p, I increased pyridoxine to about 120 mg. Only than, after taking pyridoxine at above noted dose for 10 years without any problem, did neuropathy problems start this spring, couriously in my left arm only.

Reduced the pyridoxine again, and found a new source of p5p in Europe. By taking 6x 20mg doses each day, the neuropathy gradually decreased again.
Interesting, thank you for the information, thats very helpful!