Prolactin - latest blood tests from GP

godlovesatrier

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Hello,

So my prolactin hormone level has been steadily shooting up over the last 4 months. Doctor is investigating. My latest result is below.

Serum prolactin level 506 miu/L [86.0 - 324.0]
Outside reference range
Please note raised total prolactin. This may be due to
a benign condition where prolactin binds to IgG forming
macroprolactin.

But does anyone know what prolactin binds to igg forming macroprolactin mean? And what sort of specialist would be able to investigate?

I'm due to be referred to a specialist to have this looked into further.

I'd like to point out if I hadn't got private blood tests I never would have noticed this was elevated.

I missed a few other results. My esr is still 2. 5 years after my first test!!

My ana and lupus tests are both negative which is good.

My neutrophils continue to drop - they are now 1.29. I know neutropenia is common in ME and isn't really an issue unless it drops below 1 or indeed 0.5 (severe).

However this does make me wonder if something in the Joshua Leisk protocol is doing damage. Or the vaccines are the culprit and they gave simply worsened my ME. Hard to say.
 
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godlovesatrier

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This study talks about https://academic.oup.com/jcem/article/87/12/5408/2823580

Big big prl (no joke) which is clinically referred to as macroprolactinemia if patient tumour radiology comes back negative and the patient does not have any symptoms indicative of pititory tumour.

According to studies this is very rare. Like less than 5% of patients in one sample.

But as I said in my last reply what interests me is the prolactin binding to igg. Surely that would lower igg and cause immune system problems?
 

ruben

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Hello there. You mentioned you had private blood tests. May I ask where you got these done. I asked about such test the other day. I am in suffolk UK. Thanks in advance
 

ljimbo423

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But does anyone know what prolactin binds to igg forming macroprolactin mean?
I don't know if this is something you've already found out. If your prolactin is elevated because it's binding to IGG, it seems to be harmless according to wikipedia-

Macroprolactin is a physiologically inactive form of prolactin found in a small proportion of people. It is in fact prolactin bound to IgG. Macroprolactin is important, as some laboratory assays will detect it as prolactin, leading to a falsely elevated prolactin result.
https://en.wikipedia.org/wiki/Macroprolactin
 

godlovesatrier

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@ruben you want to purchase a full blood count or ultimate performance blood test from medichecks. At order page select clinic so you can get your blood drawn at a nearby clinic.

This will give you a snapshot of your health.

Ah it's inactive interesting. Well I need a specialist test before macroprolactin can be proven as the issue. But I have a hunch it probably is. Because I haven't really got any symptoms that go along with it. But I didn't know it was inactive. Although I worry it could be reducing igg and if igg subclasses are already deficient this could exacerbate underlying immune strength.

I must say though I don't believe any of this is remotely related to the ME cause because the flu vaccine has reduced my function quite dramatically as have seasonal colds and yet before the vaccine my ME was actually in a pretty decent place.

Thanks for the replies both :)
 

Shanti1

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This study talks about macroprolactin and igg. Just a thought if igg is low or igg subclasses are low. Could this be due to prolactin binding to igg to create macroprolactin?
Since the IgG the prolactin is binding to are specifically "anti-prolactin antibodies", and it isn't binding to all IgG indiscriminately, I think it is unlikely it would cause a drop in IgG https://pubmed.ncbi.nlm.nih.gov/9284753/.

I would think an endocrinologist would be the best-suited practitioner.
 
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Just had a reply from hematology.

They said neutropenia isn't uncommon after acute glandular fever. But my blood tests returned to normal around April with regard to neutrophils but only went downhill after my covid vaccines. The interesting thing is that the hematologist goes on to say that covid 19 vaccines...yes vaccines can cause neutropenia. I was very surprised to see an NHS doctor admit to this.

Exact wording:
"Such post viral problems are often see in patients after covid jab."

I think if they are saying this there's a high likelihood they must be seeing it regularly or why say it with such certainty? I've never heard of a vaccine causing neutropenia and I've researched it to death and that never popped up anywhere.

All I'll say is Joshua Leisk was convinced it was caused by the covid vaccines.

I've decided not to get my booster for the time being. I'm starting not to trust these vaccines for those of us who are already in a fragile state. Also covid19vax.com quite clearly shows that mRNA vaccines have a much higher incidence of rare conditions and rare reactions occuring Vs the j&j and az vaccines. Going off there stats.

Apparently Dr Yaeger has recommended LC patients do not get the vaccines because of what she has seen the vaccines do to the blood.
Joshua Leisk has seen exactly the same (red blood cell abnormalities under microscope) and I've posted the blood slides from his citizen science work on other threads. So it seems to all connect up quite well. Covid vaccines do something to the blood and I'm not sure we can call it purely hyper coagulation.

@Martin aka paused||M.E. @Countrygirl @Nuno @hapl808
 

ljimbo423

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Learner1

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Joshua Leisk has seen exactly the same (red blood cell abnormalities under microscope) and I've posted the blood slides from his citizen science work on other threads. So it seems to all connect up quite well. Covid vaccines do something to the blood and I'm not sure we can call it purely hyper coagulation.
Joshua also says NAC and bicarbonate will reverse the blood coagulation after the COVID vaccine. Getting the vaccine bears dying of COVID.