Probiotics raise endogenous GABA?

Marco

Grrrrrrr!
Messages
2,386
Likes
3,225
Location
Near Cognac, France
An easy read :

‘Giving these animals these probiotics increased GABA, so it’s almost like giving them these drugs but it’s their own bodies producing GABA,’ he said.

‘So your own body is increasing this neurotransmitter that reduces anxiety.’

In addition to the animal studies, a number of human trials have been conducted in which probiotics were shown to reduce depression and anxiety symptoms.
http://www.dailymail.co.uk/health/a...help-tackle-social-anxiety-study-reveals.html
 

Crux

Senior Member
Messages
1,441
Likes
1,345
Location
USA
I wish it were that simple.

Now that I'm back to trying some individual strains, and I really need GABA, I'm going to try Lactobacillus Rhamnosus for GABA production and increased GABA receptor expression.

It worked on animals.....?

Converts glutamate to GABA, in testing.

Don't know, hope so.
 

xena

Senior Member
Messages
223
Likes
217
I wish it were that simple.

Now that I'm back to trying some individual strains, and I really need GABA, I'm going to try Lactobacillus Rhamnosus for GABA production and increased GABA receptor expression.
@Crux
i'm gonna try it too. also because i saw a paper cited showing rhamnosus could degrade mycotoxins in the body (in mice and chickens or something...) i was thinking about

how is it going?
 

Scarecrow

Revolting Peasant
Messages
1,904
Likes
5,338
Location
Scotland
https://www.ncbi.nlm.nih.gov/pubmed/10381791
J Pharmacol Exp Ther. 1999 Jul;290(1):303-9.
gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.
Gobaille S1, Hechler V, Andriamampandry C, Kemmel V, Maitre M.

Abstract
gamma-Hydroxybutyrate possesses most of the properties of a neurotransmitter/neuromodulator that acts via specific pathways and receptors in brain. Beside its regulatory effects on dopaminergic transmission, gamma-hydroxybutyrate was thought for many years to interfere with gamma-aminobutyric acid (GABA)ergic processes in the brain. The present study demonstrates that in the rat frontal cortex in vivo, gamma-hydroxybutyrate or its agonist NCS-356 administered systemically at a high dose (500 mg/kg) increases GABA contents in dialysates via a mechanism blocked by the peripheral administration of the gamma-hydroxybutyrate antagonist NCS-382. Under the same conditions, the extracellular concentration of this amino acid was not modified in the hippocampus. However, when administered at a low dose (250 mg/kg), gamma-hydroxybutyrate decreases GABA content of the dialysates of the frontal cortex by an NCS-382-sensitive mechanism. Spontaneous [3H]GABA release was observed in the frontal cortex of rats at 160 min after i.p. [3H]-gamma-hydroxybutyrate administration. This result indicates that gamma-hydroxybutyrate in vivo could be the precursor of an extracellular GABA pool in the frontal cortex. After i.p. [3H]-gamma-hydroxybutyrate administration in the rat, the amino acid contents of several brain regions were quantified 160 min later, and the radioactivity in each region was measured. [3H]GABA, [3H]glutamate, and [3H]glycine were detected in most, but not all, of the brain regions studied. In particular, radioactive GABA was not detected in the hippocampus. The other amino acids were not labeled. These results show that gamma-hydroxybutyrate modulates the synthesis and the extracellular concentrations of GABA in specific regions of the rat brain. Identification of these GABA pools and determination of their functional role remain to be defined.
According to wiki [:redface:], hydroxybutyric acids "can be viewed as derivatives of butyric acid". I'm not sure what the significance of 'can be' is in the context of mammalian physiology. Can anyone help?

Butyric acid is a product of gut bacteria, notably Clostridium butyricum - see this thread.

Incidentally, the sodium salt of gamma-Hydroxybutyric acid is sodium oxybate (trade name Xyrem) - see this thread.
 

Gondwanaland

Senior Member
Messages
5,057
Likes
4,277
I am looking for suggestions to counter excessive GABA in the morning following taking probx at bed time in the previous night. At 6:30 I take my T3/T4 replacement which isn't enough anymore to take me out of bed. I will try to take a higher dose of it but I had detrimental effects in the past (tension in the face muscles, i.e. violent teeth clenching :nervous:). I just won't wake up before 10 when I have taken probx. At least I am having interesting dreams and sleeping very well :sleep: ( @JPV )