I've certainly stuck 'probiotics' up my nose to clear a persistent nasal Staph. Aureaus infection, which was spreading and causing some sinusitis. I had surgery to remove a pituitary tumor (acromegaly) via the nose in February last year. Afterwards the mucosal lining had a lof of persistent 'crusting' (they really call it that) for 18 months, which quickly became infected. The method worked and the problem has stayed fixed, whereas it just came back after oral or topical antibiotics. The medical literature makes it pretty clear that antibiotics seldom solve a nasal staph infection, so I tried something else.....
Here's are the things I did to clear it.
1) Lactobacillus Sakei topically
2) Snot transplants!
3) Zinc supplementation
4) Mechanical resting of the nostril
1) There is one small paper written about Lactobacillus Sakei for sinusitus, which is described in detail on
http://lactobacto.com. That site also describes how to source and use it. Basically, mix it with a bit of water and stick it up your nose with a finger, but not too far. The sources are either bio cultures for meat, produced by Christian Hansen, or some varieties of Korean fermented vegetable kimichi. The CRH Hansen product they talk about on lactobacto.com is a starter culture for european fermented meat/salami called Bactoferm, which is L. Sakei plus something else. CHR Hansen also does a bio protective culture for meat which contains L. Sakei only, simply called B2. That is the one I used. This gave quite a quick result but too much seemed a bit aggravating - once every third day seemed about right for me.
2) Before the L. Sakei experiment I tried snot transplants, because if faecal transplants work for C. Diff, maybe it would be worth a try. I spoke to an ENT specialist about this beforehand, he seemed relaxed about it even though, post-op, I have a lot fewer layers between my sinuses and brain than most people. The strategy was to send my partner for a walk in cold winter weather and get a liquid sample blown into a small container. At first I used a finger to administer but then I changed to disposable plastic dropper pipettes because it's kind of gross and slimy! When the staph growth was heavy, I had to do this almost every day to make progress. The healthy nose microbiome is quite varied, so it made sense to me to introduce variety post antibiotic, but this is a completely experimental approach.
3) Later in the process I found I had a Zinc defficiency. After supplementing zinc, I feel that the probiotic methods worked a lot better and I haven't had to repeat anything. About 10 days further probiotic treatment and it was all gone.
4) Because my problem was partly post-op crusting harbouring Staph, I had to do something to get the crusting out of there, but I'm not sure if it's much use for those who haven't had surgery. The primary problem is the nose isn't moist enough once the mucosa is damaged by surgery. I read about something called modified Young's operation, which closes the nostril to stop air flow drying it out while it heals. So I taped over most of the opening of the damaged nostril at night, leaving only a 3mm hole to breath through on that side, to stop it drying much over night when there is little snot production. The final step was completely blocking it off for half an hour or so in the morning, when mucous production picks up, which was enough to allow me to blow those softened up boogers out. Woohoo. I'm keeping on with this till the nose has healed better so the crusting doesn't come back.
Hope this info helps someone but use at your own risk, nothing here is tried or tested!