Potential Suramin Alternatives - Sytrinol and Kudzu (Anti Purinergic Therapy)

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@Learner1
i had a doctor at one point (dealt with vets and combats sports) that was convinced injuring to the brain was causing inflamation and then downstream hormone disruption. So his thing was the best done hormone replacement. that is, with least side effects, lowest dosages, etc. For guys the most common was testosterone.

i was shocked to find my testosterone was low. has been for 10 years. And i did try replacement. more boners for sure. but depression, lack of focus, energy did not change. this was a 6 week trial. I feel like once you get on that bus it's hard to get back off. the erections were nice....but not at the cost of being on T for the rest of my life some what may in terms of side effects. I did realize one thing: my hormones (T, cortisol, maybe thyroid) are not where they should be.

there is also an anti inflammatory theory on how many antidepressant drugs work. and in fact many do take 1-3 months to kick in. that was the case with me and wellbutrin. i know this theory has been attacked but I have found good evidence that at least wellbutrin dramatically reduced some inflammation markers. however i suspect "inflamation" is about as general a terms as depression of CFS. And even if it does this there is no proof that it's the mechanism. the official theory is also far from solid imo. re-uptake.

my personal experience has told me i should not get over invested in any theory or treatment no matter how much sense it makes on paper. i spent 2 years devoted to chelation. that should have been 6 months. i basically ask my doctors these days how long it will take for thier suggestions to bare results. no results and i'm done. most doctors have a blind spot when it comes to admitting their approach isn't working.

i am dabbling with herbs at the moment. Tulsi, bacopa, artemisia. The tulsi showed a lot of promise after maybe 3 week on and now has waned to the point i'm unsure. In my mind the anti inflamatory window of response is 3 months. no effect in that time and i move on.
 
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Isn't it odd your inflammation is still high after so many successful interventions for infections and toxins?[/QUO
Appreciate the revival of this thread @pattismith, some of it chimes with me.

Particularly the stuff about IL-6 and TNF-alpha - I've recently discovered cumin has significant effects on my fatigue and the active ingredient cuminaldehyde suppresses these...

Has anybody on PR been known to have tried Suramin?

Or has anybody tried anything based off this thread?
Rupatadine suppresses tnf alpha , as well as histamine and stabilizing mast cells
 

Learner1

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@cporro

My doctor, a ME/CFS specialist, told me the reason I'm on naltrexone is to reduce brain inflammation.

Normalizing hormone levels can be extremely helpful. Many have low thyroid or cortisol levels which can dramatically affect metabolism or energy production.

I've found two concepts are worthwhile:

1) interventions work as part of complex biochemical systems. Adding a single intervention while neglecting other necessary substrates may create a situation that makes the intervention less than successful.

2) improving multiple processes over time takes a great deal of patients. It's not as simple as getting fixed by finding the right pill - we may have had one or more initiating triggers, but a cascade of other issues has happened since, so it's not easy to put the genie back into the bottle. A systematic approach is better.