The microRNA the article mentions, microRNA-142 (miR-142), has shown up previously in at least one ME/CFS study...miR-142-5p was found to be upregulated.
To quote the above article: "Moreover, the ability of celastrol to pass the brain blood barrier makes this compound an attractive therapeutic option in brain tumors and brain metastasis ..."
Isn't the inability of NSAIDs etc. to cross the brain blood barrier what Jarred Younger has said is the big hurdle with using these agents to treat ME/CFS??
For whatever it's worth, this stuff is available on Amazon.