View attachment 5021
...and maybe we can figure these out together?
What I don't understand (among many other things) is my a-ketoglutaric acid is basically normal, but the things that precede it are low.
After that, succinic acid drops big time, so I guess that means I need more of the co-factors...and then things drop even lower with basically no malice acid.
No wonder I can hardly walk.
A year and a half later, I think I finally figured out another piece of the puzzle.
I've long suspected that I had and still have a huge issue with salicylates/phenols. Every time I try to eat like a 'normal person', I'll experience much, much worse symptoms in the following days.
And sure enough, what else (besides heavy metals, lack of cofactors) causes an inhbition at a-ketoglutaric acid?
Salicylates.
Several studies note this, but here's a simple chart showing it:
http://www.derangedphysiology.com/p...idosis/lactic-acidosis-due-to-salycylates.php
And here's one study that mentions sals and kreb's cycle inhibition:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651525/"It is shown that inhibition in succinate dehydrogenase and α-ketoglutarate dehydrogenase by salicylate contributes substantially to the cumulative inhibition of the Krebs cycle by salicylates."
And as Caledonia says above, and Rich Van K told me years ago, that if this is blocked, then that means that the branched-chain amino acids will not be fed into the krebs cycle, so if the inhibition is strong enough,
then one ends up using one's own muscle for "fuel". One's muscle will be catabolized resulting in significant muscle loss, which is exactly what has happened in my case, especially in my lower legs and feet. When I can walk, I feel like I'm walking on glass, as I've lost so much muscle.
Hoping it's not too late to turn this around.