Your total glutathione looks pretty good, though still somewhat low. Your reduced glutathione is within its reference range, but still low-normal. Your oxidized glutathione is at the high end of its reference range.
Your SAMe is almost on its mean normal value, and that's good.
Your SAH is at the high end of its normal range.
Your folates aren't too bad.
I would say that your methylation cycle and folate metabolism (with the possible exception of folinic acid, aka 5-formyl THF) have been well supported. You probably have a good level of methionine, which feeds the methylation cycle. Your methionine synthase reaction appears to be running pretty well, given the relatively good level of THF, which is a product of this reaction. I usually see this one below its reference range, or barely within it.
There seems to be not quite enough flow of homocysteine from the methylation cycle into the transsulfuration pathway. This could be due to overdriving the methylation cycle somewhat. In general, another possible cause of this can be low B2 or B6, but since you were taking a B-complex, and you were taking fairly hefty dosages of methylfolate and methylB12, I think the first explanation is the more likely one in your case. As we've discussed before, I have different views from Freddd about the best dosages. Taking high dosages of methylfolate and methylB12 together removes control of the rate of the methylation cycle from the cells, overdriving the methylation cycle.
You might benefit by lowering these dosages somewhat.
Your high-normal oxidized glutathione means that your body is under oxidative stress. This could be due to inflammation produced by the immune system in response to one or more infections. You would probably benefit by trying to determine what is producing the oxidative stress, and treating it if possible.
As I've been posting lately, I believe that the methylation protocols address the core of the pathophysiology in ME/CFS, and I think that you have done this fairly well. However, the methylation treatments do not directly address the etiologies that are placing demands on glutathione. I think that infections and toxins are the main categories that are doing this, and infections seem to be the major one. Once infections become entrenched, even a restored immune system does not seem to be able to knock them all out, because they have ways of foiling the immune system or hiding from it. In my view, this is where the remaining challenges lie in conquering ME/CFS. I am heartened by the considerable number of good researchers who are now addressing this aspect, and I hope that we will see good progress there soon.
Best regards,
Rich