My ANA is high, 1280, diffused. This is the highest it has been. Though for the past 2.5 yrs it has hovered 640, 320, now 1280. Tests for lupus, ra, sjorgens all neg. Oddly, when my symptoms flare, the ANA goes up. They tell me it's a phenomenon that makes more work for the Rheumatologists. I don't believe it. There has to be a connection