Oberon
Senior Member
- Messages
- 214
Hi Everyone,
I was hoping to get some second opinions on what may have caused some of my recent issues. I have been playing around with methylation for almost a year and had some improvements in energy and mental state up until this year so I took a break from methylfolate and maintained my other supplements.
I am always continuously tweaking things based on things I read and the advice of this forum and It appears I've screwed something up rather badly this time around. I started taking methylfolate again this week (aside from what's in my B-Complex) and wound up with the following symptoms:
1. Extreme depression (psych ward level)
2. Tingling legs
3. Racing thoughts
4. Palpitations
5. Anxiety
My dosage was ramped up from 800mcg to 6000mcg over the span of two weeks. Other supplements I've been taking are the following:
1 B12Oils spray of Methyl/Adenosyl
1 Swanson Bioavalable B-Complex
1 Tablespoon of Jarrow Liquid Carnitine
5000IU Vitamin D
200mg Selenium
200mg Magnesium
Low dose multi-mineral complex
Low dose Iodine
All of the above I have been taking for at minimum 2 months (some for years) and haven't had any major reactions to them.
The only major differentiating factor is the Methylfolate, but where things are interesting I used to be able to take 15mg of Metafolin without any major issues and found it really helped with my depression. (I am homozygous MTHFR C677T)
_________________________________________
The other confusing factor is this is not the first time this has happened. This also happened in January 2016 where I tried a similar experiment with Methylfolate and wound up in the ER taking ativan on a daily basis until things wound down.
_________________________________________
My first instinct is potassium, but my results have been within range including when I had my blood test today 3.9 (Range of 3.5-4.9). I tried taking 200mg of Potassium today and it seemed to make the problem worse rather than better. This is also what happened back in January where I seemed to have developed a permanent acid reflux problem from taking potassium.
One other thought was I tried taking Niacin to damper things down which seemed to work until 4 hours later where everything went haywire again and the depression was way worse.
_________________________________________
Right now I'm still feeling fairly depressed and have tingling legs. My heart rate has mostly normalized. I'll probably be taking ativan again for a few days in hope things calm down.
The only thing that was elevated on my bloodwork today was my Creatinine level, which I'm not sure could explain this.
Any thoughts or opinions on what may have caused this would be tremendously appreciated, especially on the extreme depression front.
I was hoping to get some second opinions on what may have caused some of my recent issues. I have been playing around with methylation for almost a year and had some improvements in energy and mental state up until this year so I took a break from methylfolate and maintained my other supplements.
I am always continuously tweaking things based on things I read and the advice of this forum and It appears I've screwed something up rather badly this time around. I started taking methylfolate again this week (aside from what's in my B-Complex) and wound up with the following symptoms:
1. Extreme depression (psych ward level)
2. Tingling legs
3. Racing thoughts
4. Palpitations
5. Anxiety
My dosage was ramped up from 800mcg to 6000mcg over the span of two weeks. Other supplements I've been taking are the following:
1 B12Oils spray of Methyl/Adenosyl
1 Swanson Bioavalable B-Complex
1 Tablespoon of Jarrow Liquid Carnitine
5000IU Vitamin D
200mg Selenium
200mg Magnesium
Low dose multi-mineral complex
Low dose Iodine
All of the above I have been taking for at minimum 2 months (some for years) and haven't had any major reactions to them.
The only major differentiating factor is the Methylfolate, but where things are interesting I used to be able to take 15mg of Metafolin without any major issues and found it really helped with my depression. (I am homozygous MTHFR C677T)
_________________________________________
The other confusing factor is this is not the first time this has happened. This also happened in January 2016 where I tried a similar experiment with Methylfolate and wound up in the ER taking ativan on a daily basis until things wound down.
_________________________________________
My first instinct is potassium, but my results have been within range including when I had my blood test today 3.9 (Range of 3.5-4.9). I tried taking 200mg of Potassium today and it seemed to make the problem worse rather than better. This is also what happened back in January where I seemed to have developed a permanent acid reflux problem from taking potassium.
One other thought was I tried taking Niacin to damper things down which seemed to work until 4 hours later where everything went haywire again and the depression was way worse.
_________________________________________
Right now I'm still feeling fairly depressed and have tingling legs. My heart rate has mostly normalized. I'll probably be taking ativan again for a few days in hope things calm down.
The only thing that was elevated on my bloodwork today was my Creatinine level, which I'm not sure could explain this.
Any thoughts or opinions on what may have caused this would be tremendously appreciated, especially on the extreme depression front.