Here's the 23andMe data I have for the SNPs which Yasko tests for, for 18 ME patients and 18 controls matched by maternal haplogroup (as an approximation of ethnicity). The Yasko SNPs where everyone has exactly the same version as each other are excluded (2 SNPs), as well as duplicate SNPs where everyone has the same result for multiple SNPs (3 SNPs).
Missense mutations are in bold red underlined font. The cell colors reflect how Yasko flags them. Included in the "Diff" columns is the difference between each group (patients or controls) and the closest prevalence results (patients or controls or general population MAF).
So while there is some variation for ME patients compared to controls and the general population, it's quite small ... alleles of only 3 SNPs are around 10% more common in ME patients. Whereas the controls have several SNPs where they have 15-20% increased prevalence of minor alleles.
The most interesting increase for ME patients would be the number of people with homozygous MTHFR C677T or potentially compound heterozygous status with MTHFR A1298C. 5 ME patients are homozygous for C677T, compared to 1 control. 2 ME patients are potentially compound heterozygous for C677T and A1298C and 3 controls are potentially compound heterozygous. Because 23andMe doesn't indicate if the two mutations are on different strands, there's only a 50/50 chance of compound heterozygous status for those who are heterozygous for both SNPs. Hence 5-7 ME patients have MTHFR function reduced to 30%, compared to 1-4 controls.
But on the flip side, we have more patients with no MTHFR impact, compared with controls. Hence the controls have at least 11 members with 65% functionality of MTHFR, versus 5 ME patients. Hence the small difference of only 9% in overall minor allele prevalence at C677T.
So there might be a small increase in the prevalence of significant MTHFR mutations among ME patients. But it's
much smaller than the claims of 40-75% increased prevalence, etc. And due to the small sample size, the differences shown above probably aren't statistically significant. Hence these results might be indicative of a modest but significant difference which could be verified in a larger sample, or it might just be a false positive - random luck of the draw.