Ravn
Senior Member
- Messages
- 147
Please bear with me, this is my first attempt at creating a poll. I hope it works.
There are quite a few threads here where people report various issues with sun exposure. I myself have always had polymorphic light eruption, it runs in my mother's family. Then I came across this link and it felt a bit like déjà vu: “impaired T–cell function, altered production of cytokines, immune suppression...” Now where have I seen these words before...?
So, I got curious. Could there be an underlying weakness - genetic, immune, whatever - that predisposes some of us to get both PMLE and ME? Of course a poll won't really answer that but I've always wanted to create a poll, just needed a topic.
***https://www.dermnetnz.org/topics/polymorphic-light-eruption/
From the link: “Genetic factors may be important with many affected individuals reporting a family history of PMLE. PMLE is caused by a delayed hypersensitivity reaction to a compound in the skin that is altered by exposure to ultraviolet radiation (UVR). UVR leads to impaired T–cell function and altered production of cytokines in affected individuals. There is a reduction in the normal UV–induced immune suppression in the skin. This has been suggested to be related to oestrogen, insufficiency of vitamin D, or to the microbiome and antimicrobial factors.”
There are quite a few threads here where people report various issues with sun exposure. I myself have always had polymorphic light eruption, it runs in my mother's family. Then I came across this link and it felt a bit like déjà vu: “impaired T–cell function, altered production of cytokines, immune suppression...” Now where have I seen these words before...?
So, I got curious. Could there be an underlying weakness - genetic, immune, whatever - that predisposes some of us to get both PMLE and ME? Of course a poll won't really answer that but I've always wanted to create a poll, just needed a topic.
***https://www.dermnetnz.org/topics/polymorphic-light-eruption/
From the link: “Genetic factors may be important with many affected individuals reporting a family history of PMLE. PMLE is caused by a delayed hypersensitivity reaction to a compound in the skin that is altered by exposure to ultraviolet radiation (UVR). UVR leads to impaired T–cell function and altered production of cytokines in affected individuals. There is a reduction in the normal UV–induced immune suppression in the skin. This has been suggested to be related to oestrogen, insufficiency of vitamin D, or to the microbiome and antimicrobial factors.”