I found a local supposed ME/CFS specialist and have seen her a couple times, but the only treatment she offers is glutathione shots. She also discouraged me from getting my IgA and IgM levels tested after my IgG came back normal. I want to get more immune tests done but I'm not sure if she would be on board with that. Her ME/CFS knowledge also felt a bit outdated to me.
The only other options I'm aware of are flying to either OMI in California or Dr. Klimas in Florida. Again, plenty of immunologists locally, but not sure if they'd be on board with more immune tests either since my CBC was normal.
Glutathione can be useful, but there's a lot more to it than just glutathione depletion. What is depleting glutathione?
Really, any doctor can run tests. They just have to want to.
Immunoglobulins can change over time, so getting retested, especially if they're on the low end of normal, might be smart. And testing subclasses. Over time, my total IgG went from above 800 to below 600, and at one point, total IgG was just above 700 but subclasses 1 and 3, which fight viral and bacterial infections, were low. And my IgM went from low normal to 2/3 from 0 to the bottom of the range.
You could have a T lymphocyte panel run, and cytokines tested. And be tested for herpes family viruses, Parvovirus, Cocksackie virus, any other virus common to where you live or have travelled, mycoplasma and chlamydia pneumoniae, and Lyme and co-infections. Almost all are available through LabCorp.
You could have a tilt table test for POTS. A CPET test for PEM. Tests for histamine, tryptase, prostaglandin D2, Chromagranin A for MCAS. ANA and antibody tests for weird auto immune issues.
Nutrient testing to look for B vitamin, antioxidant, amino acid, fatty acid, or mineral deficiencies. A SIBO test and a stool test for intestinal parasites, microbiome imbalances, and candida. Heavy metal testing. SED rate, hs-CRP, serum ferritin, iron panel, ceruloplasmin, homocysteine. Thyroid, adrenal, pituitary, hypothalamus, and sex hormone levels.
These doctors get paid a lot of money. They are smart. Unfortunately, they were diligent, rule following students, raised by a system that teaches them to "look for horses, not zebras."
If you're really that sick, something will be off in testing. And if your doctor is clueless at that point about how to help you, you'll at least have a nice stack of test results to take to a real expert who can work on fixing you.
Theres something to be said for getting testing locally before inconveniencing yourself to fly across the country. I hear there are a few doctors in Houston. Maybe you can find one to help you...
Good luck!