Demepivo
Dolores Abernathy
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There is a transcript of Chris Armstrong's Stanford presentation here along with various diagrams showing healthy & low energy states
https://www.melbournebioanalytics.org/metabolism-chris-armstrong-written-transcription/
"AMPK (adenosine monophosphate-activated protein kinase) is important to note. It is a major protein metabolic switch within cells"
"First off, AMPK detects that there are low nutrients and energy. It turns on like a switch and, once the switch is on, AMPK prioritises the use of mitochondria for efficient energy production, and diverts resources away from other processes, because it sense the low energy environment.
The body wants to make energy in the most efficient way per molecule that it can. So, fats and amino acids, which would usually be used for cell proteins and cell fats, are diverted to make energy. This process requires oxygen and the end-products of glycolysis will also be used to make energy this way. When nutrient deprivation continues for a longer period then glucose becomes important for fuelling muscles and the brain, in this instance the end-products of glycolysis are increasingly used to form glucose via gluconeogenesis instead of being used to make ATP by mitochondria."
https://www.melbournebioanalytics.org/metabolism-chris-armstrong-written-transcription/
"AMPK (adenosine monophosphate-activated protein kinase) is important to note. It is a major protein metabolic switch within cells"
"First off, AMPK detects that there are low nutrients and energy. It turns on like a switch and, once the switch is on, AMPK prioritises the use of mitochondria for efficient energy production, and diverts resources away from other processes, because it sense the low energy environment.
The body wants to make energy in the most efficient way per molecule that it can. So, fats and amino acids, which would usually be used for cell proteins and cell fats, are diverted to make energy. This process requires oxygen and the end-products of glycolysis will also be used to make energy this way. When nutrient deprivation continues for a longer period then glucose becomes important for fuelling muscles and the brain, in this instance the end-products of glycolysis are increasingly used to form glucose via gluconeogenesis instead of being used to make ATP by mitochondria."
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