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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I can't get excited about it, because I don't seem to suffer from abnormal skeletal muscle fatigue. I do suffer from abnormal cognitive fatigue, particularly during PEM.
In youth, AMPK is more activated and helps protect against obesity and diabetes.
As we grow older, cellular AMPK activation decreases, weight gain often follows, and we are more likely to succumb to the destructive factors of aging.
AMPK Promotes Longevity And Reduces Fat Storage
- The science of bioenergetics is producing paradigm-shifting discoveries, including the role of AMPK in regulating the ways our bodies use and transform energy.
- AMPK is the “switch” that is the link between metabolic disease, inflammation, and longevity. This “switch” tells our cells when to store and generate energy-containing molecules such as fat, and when to “hunker down” and use existing energy stores.
- When switched “on,” AMPK triggers the use of stored energy from fats, enhances removal of fats and sugar from the blood, increases production of mitochondria, and reduces inflammation and cellular “junk.”
- Calorie restriction and vigorous exercise activate AMPK, shrinking body fat stores (especially in the belly region), lowering blood sugar and lipid levels, and producing other beneficial effects that retard the aging process.
- The drug metformin also activates AMPK, with similar body-wide results.
- A pair of natural botanical extracts have now been found to activate AMPK, reducing belly fat, cholesterol, blood sugar, and insulin levels.
- Instead of combating longevity threats using multiple drugs, supplementation with AMPK-activating botanicals can address these problems at its source.
- Age-induced risk factors can be tackled efficiently by boosting AMPK activity with Gynostemma pentaphyllum and trans-tiliroside from rose hips.
It sounded like from Chris Armstrong's OMF presentation, that longterm AMPK activation can drive bacterial overgrowth in the Colon because protein and fat does not end up processed correctly in the small intestine correctly, due to a lack of bile and enzymes driven by the AMPK switch.
The whole thing is a bit confusing to me right now, Chris's presentation made the case that AMPK may already be activated in patients suffering from CFS, in a long term way which could be driving gut disbiosys, and subsequently microglial activation via the vagus nerve (causing cognitive impairment)
I would love to hear Chris Armstrong's view on this treatment strategy, or any other OMF representatives.
It's interesting that people are reporting metformin is not helpful in real life.