I started with 800 mcg and quickly developed symptoms of paradoxical folate deficiency. Within a couple weeks I was taking around 4 mg of Metafolin a day. I've been taking around that much for well over a year, and during that time I've felt healthier than I have in the past 20 years.
Is it safe? Deplin is the prescription form of metafolin which is prescribed in doses of 15mg or 30mg a day. So there have been studies done, and I'm not aware of any dangers taking those high doses. That said, I don't think we have any long term studies. For me, I think it is more unsafe not to take it. My nerves were deteriorating. Numbness was becoming more frequent and more severe. I used to catch every cold that came around and it would put me in bed with respiratory infections for a week 3 or 4 times a year. I got sick once last year, and I wasn't bed bound. So I think my immune system is more or less like that of most people now. We all have to make our own decisions about what we do with our bodies and what we put in them. For me, taking higher doses of Metafolin is a pretty easy one.
Curious to know how you are doing now.
I hit a wall with the Freddd protocol every time. It's great for a while, then I crash: Weakness, fatigue, huge abdominal tension, inability to handle work, "don't like anything", "don't want anything", jittery, anxiety, anhedonia, no concentration, cold hands & feet.
Correct me if I'm wrong, but these mostly aren't paradoxical folate deficiency symptoms. Also, I do not have the common PFD symptoms Fred lists - e.g. angular chelitis, peeling skin...
LCF appears cause this syndrome more than the other DQs, however it can also happen without LCF.
When this happens I take at least 3g of potassium chloride p day (sometimes 6g), but that doesn't seem to solve the problem.
So as I am on the same starting dose of m-folate as you, I might give increased m-folate a shot.
Did you increase your mB12 at the same time? I.e. does the mB12 need to "keep up" with the m-folate?
Thanks...