Has anyone tried PEA supplements to help with their inflammation and symptoms? I'm curious to hear from anyone who has tried it. I'm thinking about experimenting with it.
I didn't feel confident with alternative products that may or may not be processed correctly or have the actual active ingredient.
*Very useful for pain relief*
PEA (Palmitoylethanolamide), from a comment on https://www.healthrising.org/blog/2...-fibromyalgia-chronic-fatigue-syndrome-mecfs/:
Fantastic News! I have been in extreme pain for about a year (and stuck in bed). There’s been a question as to how much of the pain is CFS related, how much because of degenerative disc disease, and how much might be caused by something like MS. I have been using 3000 mg/day gabapentin and 75 mg/day baclofen (max doses for both). Even then, I was supplementing with small amounts of oxycontin (during the day, especially on days when I got in the shower) or carisoprodol (during the night).
I was still having partial seizures (probably not associated with CFS?) related to the neurological symptoms and pain, and other pain related symptoms. I started to notice a slight but noticeable lessening of pain on about day 6 of emptying the PEA capsule under my tongue. The pain level has continued to decrease!!! Wonderful!!! I haven’t used any more oxycontin and I’ve needed less and less carisoprodol. And PEA works without any “fuzziness”, etc. or a prescription! These over-the-counter things are my favorite! No need to try to convince a doctor that I should try it.
*Calming glia and mast cells*
Note from Jan M Keppel Hesselink · Instituut voor Neuropathische Pijn:
Palmitoylethanolamide, a lipid signaling PPAR alpha agonist, clearly inhibits overactive glia cells and mast cells. We use it frequently in neuropathic pains and it has a very impressive effect in some patients.
From (good article) https://www.healthrising.org/blog/2...-fibromyalgia-chronic-fatigue-syndrome-mecfs/
Dr. Younger included PEA in his long list of potential microglial inhibitors that might be of use in Chronic Fatigue Syndrome and Fibromyalgia.
From Jacob, comment on Cort's Health Rising article:
LDN and PEA go together, quite good actually for treatment of resistant chronic pain syndromes.
From Jammy88 on PR:
I take it, as suggested by my neurologist. Great supplement! I buy it on PeaVera.com and I take 2-3 capsules a day, depending on how I feel. Each capsule is 400mg. It mainly eases my neurological symptoms (paresthesias, etc). It's also indicated to ease fibromyalgic pain.
I started taking it in October and have been pretty constant for the first 3-4 months. Now I take it a bit less frequently, so yes I guess what is said on the website is correct. Then I believe it depends on the person.
I think PEA will help with neuromuscular pain, as it is very effective in reducing neuroinflammation - which is a very common issue for the all of us on PR.
From NK17 on PR:
I've taken Normast (PEA) this past summer apparently with no real benefit.
From hixxy on PR:
Gave me weird brain side effects but I can remember the specifics as it was a about 3 years ago now. I didn't take it long enough to see if it would help in other ways.
*Top 5 worst supplements*
From nandixon on PR:
I tried PEA a couple years ago (to inhibit microglia activation), and indeed it was very bad. I normally don't have significant brain fog but the PEA I took actually caused that. It was very insidious too. Probably one of the top 5 worst supplements I've ever taken.
I had the exact same thing happen from taking perilla leaf,
Did you ever try prednisone? It gave me the same effects as cumin when I first tried it, and then stopped working.
Have to say I use pred when I need a boost. Works well for me but I don't like to use it too often - both because I don't want it to stop working, and because I know long term use of steroids isn't great for the body.Neither did I, except as an excellent umami deepener for soups, stews, etc....
Prednisone is a bridge too far for me, but if you try it, do let us know how that went, yes?
Solid good thinking .... I was worried there for a minute ....both because I don't want it to stop working, and because I know long term use of steroids isn't great for the body.
There's a lot to be worried about, that's for sureSolid good thinking .... I was worried there for a minute ....
Part of my resistance is that I was dosed with prednisone prior to each chemo session, and that was about as much of it as I want ....
You're doing it in the most responsible way possible, and for the most valid reasons .... if it does the trick, it's an essential.Can never get into the doctor in that time frame so have been self medicating for years. I don't like taking it, but it's the only thing that knocks the asthma on its head, and it got me through some pretty bad crashes too.