*Very useful for pain relief*
PEA (Palmitoylethanolamide), from a comment on
https://www.healthrising.org/blog/2...-fibromyalgia-chronic-fatigue-syndrome-mecfs/:
Fantastic News! I have been in extreme pain for about a year (and stuck in bed). There’s been a question as to how much of the pain is CFS related, how much because of degenerative disc disease, and how much might be caused by something like MS. I have been using 3000 mg/day gabapentin and 75 mg/day baclofen (max doses for both). Even then, I was supplementing with small amounts of oxycontin (during the day, especially on days when I got in the shower) or carisoprodol (during the night).
I was still having partial seizures (probably not associated with CFS?) related to the neurological symptoms and pain, and other pain related symptoms. I started to notice a slight but noticeable lessening of pain on about day 6 of emptying the PEA capsule under my tongue. The pain level has continued to decrease!!! Wonderful!!! I haven’t used any more oxycontin and I’ve needed less and less carisoprodol. And PEA works without any “fuzziness”, etc. or a prescription! These over-the-counter things are my favorite! No need to try to convince a doctor that I should try it.
*Calming glia and mast cells*
Note from Jan M Keppel Hesselink · Instituut voor Neuropathische Pijn:
Palmitoylethanolamide, a lipid signaling PPAR alpha agonist, clearly inhibits overactive glia cells and mast cells. We use it frequently in neuropathic pains and it has a very impressive effect in some patients.
*Microglia*
From (good article)
https://www.healthrising.org/blog/2...-fibromyalgia-chronic-fatigue-syndrome-mecfs/
Dr. Younger included PEA in his long list of potential microglial inhibitors that might be of use in Chronic Fatigue Syndrome and Fibromyalgia.
From Jacob, comment on Cort's Health Rising article:
LDN and PEA go together, quite good actually for treatment of resistant chronic pain syndromes.
*Great*
From Jammy88 on PR:
I take it, as suggested by my neurologist. Great supplement! I buy it on PeaVera.com and I take 2-3 capsules a day, depending on how I feel. Each capsule is 400mg. It mainly eases my neurological symptoms (paresthesias, etc). It's also indicated to ease fibromyalgic pain.
I started taking it in October and have been pretty constant for the first 3-4 months. Now I take it a bit less frequently, so yes I guess what is said on the website is correct.

Then I believe it depends on the person.
I think PEA will help with neuromuscular pain, as it is very effective in reducing neuroinflammation - which is a very common issue for the all of us on PR.
*Neutral*
From NK17 on PR:
I've taken Normast (PEA) this past summer apparently with no real benefit.
*Not good*
From hixxy on PR:
Gave me weird brain side effects but I can remember the specifics as it was a about 3 years ago now. I didn't take it long enough to see if it would help in other ways.
*Top 5 worst supplements*
From nandixon on PR:
I tried PEA a couple years ago (to inhibit microglia activation), and indeed it was very bad. I normally don't have significant brain fog but the PEA I took actually caused that. It was very insidious too. Probably one of the top 5 worst supplements I've ever taken.