• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Oxalate is the main contributor to neurotoxicity caused by oxaliplatin

pattismith

Senior Member
Messages
3,931
Chemotherapy‑induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin‑induced neurotoxicity

"oxaliplatin (I) is rapidly hydrolyzed in vivo to bioactive derivatives through the displacement of the oxalate group by H2O and Cl− ions to produce oxalate (II) as well as reactive monochloro-diaminocyclohexane (DACH) (III), dichloroDACH (IV) and diaquo-DACH platinum (V) metabolites.

Oxalate, which reacts with Ca2+ ions, is the main contributor to neurotoxicity caused by oxaliplatin"

1602187321947.png