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Oxalate is the main contributor to neurotoxicity caused by oxaliplatin


Senior Member
Chemotherapy‑induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin‑induced neurotoxicity

"oxaliplatin (I) is rapidly hydrolyzed in vivo to bioactive derivatives through the displacement of the oxalate group by H2O and Cl− ions to produce oxalate (II) as well as reactive monochloro-diaminocyclohexane (DACH) (III), dichloroDACH (IV) and diaquo-DACH platinum (V) metabolites.

Oxalate, which reacts with Ca2+ ions, is the main contributor to neurotoxicity caused by oxaliplatin"