Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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@Judee Glad it helps. The main effect of Huperzine A is to increase available acetylcholine. My neurologist researched it after I was unable to get compounded pyridostigmine, and suggested I try 200 mg a day, which is the typical dose used for Alzheimer's patients. I think most of the supplements out there come in this dose. Have you maybe tried taking a 100 mg a day?
I have been on it for about 18 months, and haven't had any experience with buildup. I also take Benadryl for mast cells, which can reduce acetylcholine, so I think I have a decent balance. Maybe you just need a little less. Or maybe something else is out of balance.
I have hyper POTS with high blood pressure and have not found Huperzine A to be a vasconstrictor.
This only works if one has LOW blood pressure and blood volume. It can be dangerous for those who have high blood pressure forms of OI. And, even so, many if us are also on a variety of beta blockers.The simplest things to try are electrolyte drinks for increasing blood volume and support stockings for improving venous return from the legs.
I followed anti-viral program as suggested by Anthony William. Natural anti-virals used along with other supplements. I don't know if I had blood pooling in the legs or not?Did you have blood pooling in the legs? What anti viral program did you do? Very interesting btw.
Is the dysautonomia mitochondrial related? I read somewhere that low energy production causes problems with the process of compensatory mechanisms of standing and so the sympathetic system takes over and causes further problems.