ONLINE TALK with Prof Ron Davis: Progress and Challenges for a ME/CFS Diagnostic

Boba

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Maybe the graduate student did not crash BECAUSE he/she was getting better and not the other way round. At least that is my experience.. I don’t get better from not crashing.

Anyway, I like the part when Ron says, that there is no permanent damage because there are pwmes who recover completely.. I really hope this is true
I always wonder whether this is just a made up story to keep people hopeful
 

Pyrrhus

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Anyway, I like the part when Ron says, that there is no permanent damage because there are pwmes who recover completely.. I really hope this is true
I believe it too, mostly. I have had two full remissions where all my symptoms disappeared.

If it can happen temporarily, then it seems possible that it could happen permanently. (Once we know how to make it happen!)
 

SlamDancin

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Did OMF try giving patients a small dose of Levodopa (Sinemet) to see if it would help the cognitive issues?
If they did he didn’t mention it. He transitioned from the suspicion of low dopamine to talking about Abilify. In case you’re interested, I found an interesting mice study where Berberine was successful in treating Parkinson’s disease by increasing production of BH4 by gut microbiota which in turn increased the production of l-dopa through the phenylalanine-tyrosine-l-dopa pathway. The l-dopa was then transported to the brain where it increased dopamine. I’ll link it below;

https://pubmed.ncbi.nlm.nih.gov/33623004/
 

Alvin2

The good news is patients don't die the bad news..
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If they did he didn’t mention it. He transitioned from the suspicion of low dopamine to talking about Abilify. In case you’re interested, I found an interesting mice study where Berberine was successful in treating Parkinson’s disease by increasing production of BH4 by gut microbiota which in turn increased the production of l-dopa through the phenylalanine-tyrosine-l-dopa pathway. The l-dopa was then transported to the brain where it increased dopamine. I’ll link it below;

https://pubmed.ncbi.nlm.nih.gov/33623004/
Very interesting.

If Levodopa (Sinemet) helps cognition in ME then its a cheap, easily accessible treatment that any GP can prescribe (if it works).