The presence of dUTPase
protein in ME/CFS patients was first brought to our attention by Dr Martin Lerner in a 2012 study
Dr Martin Lerner theorized that herpesvirus ME/CFS is due to an abortive
herpesvirus infection. An abortive infection is one which does not produce viral particles, but smolders away inside cells on a long-term basis.
One protein made in herpesvirus abortive viral infections, as well as in regular productive herpesvirus infections, is deoxyuridine triphosphatase (dUTPase
), and this protein can be transmitted cell to cell via exosome transport. The dUTPase
protein is known
to induce ME/CFS-like symptoms. More info in this post
Ohio State found around 31% to 53% of ME/CFS patients have high levels of antibodies to the dUTPase
protein produced by EBV, HHV-6 and VZV. Ref: here
. Ohio State believe dUTPase may be a biomarker in a subset of ME/CFS patients (presumably the herpesvirus subset).