(Not on ME/CFS-specifically) "High-Intensity Exercise, Heat, and Endotoxemia"

[Dolphin]

I just came across this page and thought I'd post it somewhere on PR and this seemed like the most suitable place:

"High-Intensity Exercise, Heat, and Endotoxemia"
http://syontix.com/high-intensity-exercise-heat-and-endotoxemia/

I admit I have only skimmed it. But given the post-exertional problems in ME/CFS, I thought it might be worth a plug.

 

[Little Bluestem]

Disassembly of intestinal tight junction proteins is thought to occur due to the rapid breakdown of adenosine triphosphate (ATP) to adenosine monophophate (AMP) in intestinal cells. This causes a release of hydrogen peroxide, a potent free radical and disruptor of intestinal tight junction proteins.

Isn't breakdown of ATP to AMP hypothesized to occur in ME/CFS? I wonder if it always causes a release of hydrogen peroxide.

 

[WillowJ]

One HSP in particular, HSP70, prevents the breakdown of the tight junction protein occludin. It also protects intestinal cells from hydrogen peroxide and damage caused by low cellular oxygen.

this is a HSP which has been fingered in ME/CFS in a small study (Jammes, but not Thambirajah)

 

[Sherlock]

this is a HSP which has been implicated in ME/CFS in a small study (Jammes, but not Thambirajah)

FFTs:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2009.02079.x/full
and
http://cimonline.ca/index.php/cim/article/view/4917/1787