@lenora Thanks for your wishes and pray that all will be well with you and your family as well !
In relationship to smell/taste affecting members of your family:
SARSCoV2
Two articles recently appeared in
ACS Chemical Neuroscience that need attention.
(1,2) The article published by Bilinska et al. indicated that sustentacular cells are responsible for Severe Acute Respiratory Syndrome (SARS)-like Coronavirus (SARS-CoV-2) entry and related smell impairment.
(1) Bilinska et al. also reported that non-neuronal cells of the olfactory epithelium (OE) are more likely to be the entry point of SARS-CoV-2 virus rather than olfactory receptor neurons (ORNs).
(1) In the second report, Butowt and Bilinska highlighted the need for OE-oriented experimental studies to clarify various points related to SARS-CoV-2 virus and the continuous need for clinical data related to SARS-CoV-2 and related smell loss.
(2)
Brann et al. reported that direct involvement of olfactory sensory neurons (OSNs) may not occur in SARS-CoV-2 infection since OSNs did not express ACE2.
Non-neural cell types (e.g., stem cells, TMPRSS2 support cells, and perivascular cells) express ACE2, and they are responsible for related smell impairment.
(3)
Brann et al. hypothesized that inflammation, deteriorated signaling, and diffuse architectural damage of the OE may be the mechanisms for smell impairment.
The results are presented in
Table 1. Published studies indicated that smell impairment in SAR-CoV-2 recovered early.
At present, no treatment for SARS-CoV-2-related smell impairment exists.
In two studies, some treatments, including nasal saline irrigation, intranasal corticosteroids, systemic corticosteroids, dietary supplements, vitamin A, and olfactory training, on limited number of the subjects were reported.
(7,11)
However, no definite conclusion could be made concerning the effect of treatment on recovery rates. Smell loss mostly recovered in a few weeks after the infection and seemed to reduce with time.
https://pubs.acs.org/doi/10.1021/acschemneuro.0c00296
Other Research has demonstrated SARS-CoV-2 infection in human tissue samples of olfactory mucosa (the outer layers of tissue in the nose) and its neuronal projections into the central nervous system (CNS), indicating that the virus can exploit the olfactory system to cross into the CNS.
https://www.nature.com/articles/s41593-020-00758-5
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease.
Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals with COVID-19, SARS-CoV-2 penetrance of the CNS is likely.
By various means, we demonstrate the presence of SARS-CoV-2 RNA and protein in anatomically distinct regions of the nasopharynx and brain.
Furthermore, we describe the morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and present evidence of SARS-CoV-2 neurotropism.
SARS-CoV-2 can enter the nervous system by crossing the neural–mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings.
Subsequently, SARS-CoV-2 appears to follow neuroanatomical structures, penetrating defined neuroanatomical areas including the primary respiratory and cardiovascular control center in the medulla oblongata.
FYI:
Research on SARSCoV2 is constantly evolving. Some of my goto researchers on Twitter are of the following:
Switzerland:
Dr Emma Hodcroft @Firefoxx66 World renown Leading researcher & co-developer on NEXTSTRAIN tracking emerging viruses @ISPMBern SARSCoV2/COVID-19
https://mobile.twitter.com/firefoxx66
Australia:
Virologist Ian M. McKay PhD @MackayIM
https://mobile.twitter.com/MackayIM
Keeping Australia & the world safe with his famous Swiss Cheese Respiratory Pandemic Defense Diagram and his great guide and defense on COVID-19 PCR Testing
U.S.
Trevor Bedfor @trvrb @FredHutch
https://mobile.twitter.com/trvrb
Dr. Angela Rasmussen @angie_rasmussen
https://mobile.twitter.com/angie_rasmussen
Dr. Tom Frieden@DrTomFrieden
https://mobile.twitter.com/DrTomFrieden
Eric Feigl-Ding @DrEricDing Epidemiologist
https://mobile.twitter.com/DrEricDing
One of the first to sound the alarm on COVID-19 with his infamous "HOLY MOTHER OF GOD" clarion call. Video out of Wahun Province, China showed people suddenly dropping dead in the streets. There is a post on phoenix rising about asymptomatic individuals suddendly having cardiac failure.
There are so many other great researchers out there
NOTE: Remember with UK variant is NOW in U.S. and expected to be the dominate strain by March. Fauci is now recommending double masks or a N-95 respirator.
Stay Safe ! Best, Eco