National Centre for Neuroimmunology and Emerging Diseases - NCNEDLike Page
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NCNED describes calcium signalling disorder in CFS/ME
Our latest article (Nguyen et al., 2017) shows that certain ion channel receptors (called transient receptor potential ion channels or TRPs) responsible for calcium signalling in Natural Killer (NK) cells are defective, even when stimulated with their natural ligand.
We have used NK cells as a model to illustrate this pathology in all cells.
These current results indicate this ion channel is not functioning correctly and unable to modulate calcium in people with CFS/ME even when stimulated with its natural ligand, pregnenalone sulphate, under strictly controlled conditions.
As there are multiple TRP channels and autonomic receptors, we have identified these may also be implicated in this disabling illness.
We have clear evidence from at least two separate studies that these ion channels, as well as calcium and its signalling, are dysfunctional in CFS/ME.
Our team at NCNED is now targeting pharmacotherapeutics to treat this disorder.
NCNED is pleased to acknowledge all our donors and benefactors. Special thanks to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt and the Queensland Government for their unfailing support.