voner
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here is a post on a XMRV research project in the UK... Dr. Kate Bishop (heads a group under Dr Jonathan Stoye)
http://www.findaphd.com/search/showproject.asp?projectid=29601&searchtype=n&page=2
in this post it says:
We have already established PCR-based and serological tests for XMRV in the laboratory and are currently expanding our range of assays to include ELISA for high-throughput screening and viral culture assays. These assays will be used to study the prevalence of the virus in the general population, for example UK blood donors, and in patient groups of particular interest. We will use these epidemiological patterns to help examine possible routes of transmission of XMRV.
they go on to say:
We have shown that human restriction factors can inhibit XMRV and it has been suggested that it is also susceptible to RNase L. We will, therefore, analyse the effects of interferon treatment as well as other hormonal stimuli on XMRV infection. The mechanisms behind any enhancement or inhibition noted will be explored. We will compare XMRV replication to that of other exogenous and endogenous murine leukaemia viruses to determine general phenotypes and identify any characteristics unique to XMRV.
here's a link to Dr. Bishop's webpage:
http://www.nimr.mrc.ac.uk/research/kate-bishop/
these are the folks who couldn't find XMRV in their UK population tests of 299 patients...
http://www.ncbi.nlm.nih.gov/pubmed/20156349
but looks like Dr. Bishop's group isn't giving up...
this is the group that also found:
We found that both human APOBEC3 and tetherin proteins are able to block XMRV replication.
(http://www.ncbi.nlm.nih.gov/pubmed/20194752)
comments??
http://www.findaphd.com/search/showproject.asp?projectid=29601&searchtype=n&page=2
in this post it says:
We have already established PCR-based and serological tests for XMRV in the laboratory and are currently expanding our range of assays to include ELISA for high-throughput screening and viral culture assays. These assays will be used to study the prevalence of the virus in the general population, for example UK blood donors, and in patient groups of particular interest. We will use these epidemiological patterns to help examine possible routes of transmission of XMRV.
they go on to say:
We have shown that human restriction factors can inhibit XMRV and it has been suggested that it is also susceptible to RNase L. We will, therefore, analyse the effects of interferon treatment as well as other hormonal stimuli on XMRV infection. The mechanisms behind any enhancement or inhibition noted will be explored. We will compare XMRV replication to that of other exogenous and endogenous murine leukaemia viruses to determine general phenotypes and identify any characteristics unique to XMRV.
here's a link to Dr. Bishop's webpage:
http://www.nimr.mrc.ac.uk/research/kate-bishop/
these are the folks who couldn't find XMRV in their UK population tests of 299 patients...
http://www.ncbi.nlm.nih.gov/pubmed/20156349
but looks like Dr. Bishop's group isn't giving up...
this is the group that also found:
We found that both human APOBEC3 and tetherin proteins are able to block XMRV replication.
(http://www.ncbi.nlm.nih.gov/pubmed/20194752)
comments??