New study - 8 SNPS corresponding to CFS/ME symptoms

[Mary]

https://cfsremission.wordpress.com/2016/01/23/new-study-found-snps-for-some-symptoms/

The original study the above article is based on is here: http://www.translational-medicine.com/content/14/1/19

And I compared my SNPs to those of the person who wrote the wordpress article above, and mine were a match with him or her, except for nucleotide position 16519, where I had a C instead of a T (for more gastro symptoms). Though I didn't get a result from 23andme for 16223.

 

[adreno]

That's weird. I'm an exact match with the author. And I'm haplogroup H.

 

[John Mac]

There's already a thread on it here:
http://forums.phoenixrising.me/inde...ants-correlate-with-symptoms-in-me-cfs.42517/

 

[Mary]

There's already a thread on it here:
http://forums.phoenixrising.me/index.php?threads/mitochondrial-dna-variants-correlate-with-symptoms-in-me-cfs.42517/

There sure is - thanks for pointing this out!

 

[Mary]

That's weird. I'm an exact match with the author. And I'm haplogroup H.

I'm almost an exact match and am haplo group V.

 

[adreno]

@Valentijn would you be interested in taking a look at this?

 

[Valentijn]

MTDNA, especially the parts discussed in the recent research paper, is pretty much identical for everyone with the same haplogroup. Similarities simply mean that everyone is of European extraction in their maternal line. We don't have any increase in rare haplogroups, and when matched with controls from the same haplogroups our MTDNA SNPs are pretty much entirely identical.

Also, for many of the SNPs, it's the more common allele which was found to be associated with the more severe symptoms in some categories. So it's to be expected that a lot of ME/CFS patients would have both those symptoms and those alleles.

Beyond that, I'm not sure what you'd want me to look for. There might be ways to "help out" genes with presumed dysfunctional SNPs on them, but that's going to vary depending on which genes are involved for each person.

 

[Ellkaye]

Can this be used for improved/'cured' patients?