interesting concept. Its quite reasonable to think the adrenal glands could be worn out from constant stress of cfs. I have improved quite abit on antivirals but need to improve another 10%, a recent blood test showed my dhea levels were quite low, i believe this can be a sign of adrenal fatigue/insufficiency. Supplements of dhea have been helping, will give it abit longer and then may add adaptogens as well, although i never got alot out of them before, maybe i was too ill for them to help, now that i have overcome alot of this cfs, the last things to improve now are adrenals and sleep, which i believe can be related also.