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Some people with CFS/ME and POTS have ganglionic acetylcholine receptor antibody.
http://www.ncbi.nlm.nih.gov/pubmed/17352367
http://www.ncbi.nlm.nih.gov/pubmed/17352367
As B1 cells pump out large amounts of none specific anitbodies there could be some that can bind to acetylcholine receptors.
Then there is less acetylcholine release and receptors blocked by antibodies.