Neurotoxicity of organic solvents with emphasis on the role of iron 2021

pattismith

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Neurotoxicity of organic solvents with emphasis on the role of iron (degruyter.com)


Background
Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.

Objectives
This study investigated the role of iron in association with some neurotransmitters for diagnosis of neurotoxicity of OS.

Methods
The study included 90 workers, 50 occupationally exposed to OS and 40 representing control group. Blood samples were collected from the included subjects for determination of serum iron, total iron binding capacity (TIBC), serotonin and gamma-aminobutyric acid (GABA).

Results
Revealed reduction in serotonin level and serum iron. However, the elevation in GABA and TIBC was observed. The duration of exposure was significantly correlated with iron and serotonin while it was positively correlated with GABA and TIBC.

Conclusions
Elevated GABA and TIBC with decreased serotonin and serum iron can be used as early diagnostic measures to detect the neurotoxic effects of OS.
note: high TIBC is a marker for iron deficiency