Yes! What Freddd is saying is that when you open a priorly blocked metabolic pathway (methylation cycle) then you expose other deficiencies you had but which weren't 'active' because your biochemistry was blocked 'upstream'. That is not detox at all but it can hurt.
The bit I wanted to add is that I have THREE COMT polymorphisms - they very ones that Dr. Yasko says should not be able to tolerate methyls TIMES THREE and I have NO problem with methylcobalamin, methylfolate, or 2g TMG methyls) every day. IMHO it does not even make SENSE to take any nonactive supplement. Especially for those of you who have not had your genes mapped out...who may not even be ABLE to make methylcobalamine out of hydroxycobalamin. I do not believe the bit about 'letting your body regulate this.' Velha healed herself of chronic fatigue by this SAME reasoning...why would anyone ever think that taking a NONactive supplement could heal themselves??! Velha just took the active supplements at a low dose until bit by bit she could work out and correct her other deficiencies and raise the bar. It took her 3 months for substantial improvement and 6 months before she was well enough to go back to work. She is well because she took ACTIVE methylation supplements.
Dont be scared off by some startup symptoms. These mean the protocol is doing something and it's time to work out your other deficiencies!!
My opinion for what it's worth.
Rydra
The bit I wanted to add is that I have THREE COMT polymorphisms - they very ones that Dr. Yasko says should not be able to tolerate methyls TIMES THREE and I have NO problem with methylcobalamin, methylfolate, or 2g TMG methyls) every day. IMHO it does not even make SENSE to take any nonactive supplement. Especially for those of you who have not had your genes mapped out...who may not even be ABLE to make methylcobalamine out of hydroxycobalamin. I do not believe the bit about 'letting your body regulate this.' Velha healed herself of chronic fatigue by this SAME reasoning...why would anyone ever think that taking a NONactive supplement could heal themselves??! Velha just took the active supplements at a low dose until bit by bit she could work out and correct her other deficiencies and raise the bar. It took her 3 months for substantial improvement and 6 months before she was well enough to go back to work. She is well because she took ACTIVE methylation supplements.
Dont be scared off by some startup symptoms. These mean the protocol is doing something and it's time to work out your other deficiencies!!
My opinion for what it's worth.
Rydra
I agree that detox isn't a reason to avoid any one supplement but I can honestly say that my daughter was frankly psychotic and my metals were pouring out so fast and so heavy I couldn't take the pain anymore. As I explained to Freddd, we didn't have any problems with low potassium at all and had both urine and blood testing so I don't think its as clear cut as it is for some and this is probably due to those pesky genes.