I think it makes a lot of sense, pyruvate dehydrogenase makes Acetyl Co enzyme A which makes most of the energy humans use. Blocking it would explain a lot. Acetyl Co enzyme A also is required for the production of acetylcholine which is required by the brain. Taking Acetyl Carnitine which increases production of acetylcholine seems to be making a measurable brain function difference in myself and appears to involved in things regarding sleep, memory and so forth.
None of this completely proves this is the disease mechanism in ME/CFS, but so far i think the evidence is very supportive of it. More research will be needed to prove or disprove it which is happening now