Kitsune
Senior Member
- Messages
- 136
Hi - I've recently discovered that I am homozygous for the MTHFR polymorphism. I have started seeing a functional medicine practitioner over the internet who is advising me to start a methylated supplement by Klaire Labs with 1,000mcg methylcobalamin, 800mcg methylfolate, 30mg riboflavin, 15mg P5P, 600mg TMG. I have tried smaller and smaller doses but am overstimulated on each one. Today I tried taking 1/32 of a capsule titrated in water to a quarter, so a 1/128 of a dose - but am still getting symptoms of overstimulation (chest pain, stomach ache, anxiety).
It feels like this is all I've got left to try? I've had adrenal problems for years and am very sick with them. I take other supplements that help - vitamin C, magnesium, liposomal glutathione, zinc, fish oil and some herbs. But I really went downhill this past summer when I stopped my methylated B50 supplement to see if I felt better without it. 2 weeks later I knew I'd made a mistake, but my body would not allow me to take it again, even in small doses. The only thing I've been able to successfully reintroduce lately has been a very weak liquid methylated B-supplement, Biocare Liquid Methyl B Complex, at half a dose. It contains tiny amounts of the Bs, including 50mcg of folate at that dose. While it's almost nothing, I feel better with it than with nothing at all. But I can't seem to get up to the full dose or I get the same overstimulation problems.
I went through something similar earlier in the year - I tried an elimination diet because I have histamine intolerance, and have never been able to add back many of the foods I'd previously tolerated. I can now only eat about 20, though they are healthy Paleo.
What I'm trying to understand is why I've suddenly become reactive to things I used to be able to tolerate, such as healthy foods and my B supplement (it was Swanson). I'm trying to get my body to accept some starting dose of the new methylated supplement, however small, because it feels like that's what I need? Am I wasting my time? Should I tweak it or try something else?
Any advice would be much appreciated! I've tried many times to google reactivity to supplements and food and can't seem to get anywhere.
It feels like this is all I've got left to try? I've had adrenal problems for years and am very sick with them. I take other supplements that help - vitamin C, magnesium, liposomal glutathione, zinc, fish oil and some herbs. But I really went downhill this past summer when I stopped my methylated B50 supplement to see if I felt better without it. 2 weeks later I knew I'd made a mistake, but my body would not allow me to take it again, even in small doses. The only thing I've been able to successfully reintroduce lately has been a very weak liquid methylated B-supplement, Biocare Liquid Methyl B Complex, at half a dose. It contains tiny amounts of the Bs, including 50mcg of folate at that dose. While it's almost nothing, I feel better with it than with nothing at all. But I can't seem to get up to the full dose or I get the same overstimulation problems.
I went through something similar earlier in the year - I tried an elimination diet because I have histamine intolerance, and have never been able to add back many of the foods I'd previously tolerated. I can now only eat about 20, though they are healthy Paleo.
What I'm trying to understand is why I've suddenly become reactive to things I used to be able to tolerate, such as healthy foods and my B supplement (it was Swanson). I'm trying to get my body to accept some starting dose of the new methylated supplement, however small, because it feels like that's what I need? Am I wasting my time? Should I tweak it or try something else?
Any advice would be much appreciated! I've tried many times to google reactivity to supplements and food and can't seem to get anywhere.
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