SilverbladeTE
Senior Member
- Messages
- 3,043
- Location
- Somewhere near Glasgow, Scotland
SilverbladeTE - you have a wonderful way with words!! Made me laugh. Spot on ..
*bows with a theatrical flourish*
My pleasure
SilverbladeTE - you have a wonderful way with words!! Made me laugh. Spot on ..
Invest in ME's response to the "MRC Funding of Research into ME/CFS" news:
http://www.investinme.org/IIME Statement 2011-01-01.htm
A must-read I think.
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) – Cross-board highlight notice
This highlight notice invites the submission of high-quality proposals in priority areas within CFS/ME research, to all MRC Research Boards.
Immune dysregulation: There is evidence for a disturbance in innate and adaptive immunity in CFS/ME including alterations in cytokine profile, absolute and functional alterations in T cells and NK cells and occurrence of autoantibodies and allergic reactions that may explain some of the manifestations such as fatigue and flu-like symptoms. A number of infectious and environmental exposures have been associated as triggering these changes.
Neuropathology: There is now preliminary evidence supporting the view that inflammatory mechanisms in the brain and spinal cord may underlie the pathophysiology of some severe disease CFS/ME phenotypes. Biobanks are now becoming available and create a unique opportunity for interrogation.
http://www.mrc.ac.uk/Fundingopportunities/Highlightnotices/CFSME/MRC001747
Some interesting extracts from a recent MRC notice (I've underlined some interesting text): [...] So, maybe they did learn some lessons from the PACE Trial?
Quite so!Ironically, the latest MRC notice also seems to be implying evidence for the existence of MYALGIC ENCEPHALOMYELITIS: muscle pain and "inflammatory mechanisms in the brain and spinal cord".