Mitochondria make pregnenolone from cholesterol and this can filter down and help make other hormones etc. I think acetyl carnitine help in the conversion of cholesterol to pregnenolone. Q10 seems to play a vital mpart in this some how? several antioxidants would be helpful too.
Something called MitoQ, a derivative of Q10, has been touted recently, and is now available from ProHealth, but at a very stiff price. There is a bit of research behind it--has anyone tried it?
I have tried a couple of versions of ATP Fuel, but though a couple of people I know claim to have improved energy taking it, it did not do much for me. This is basically a Lecithin derivative, with a bunch of other things added, the mix claimed to improve the production of ATP. This might be worth a try, not cheap--but I am not clear that it is really significantly better than plain Lecithin, and that too does not do very much for me.
Chris
Cheers Chris,
I take just plain old Co-q10. It's from dr Myhill so I presume it's ok. However they suggest ubiqunol On line don't they......? Does it make much difference I wonder....?
I have noted some patients feel no difference with the Q10 recommended by Myhill. I bought it and it has never made any difference to me. However those same people have switched to Ubiquinol and found it effective. It is VERY expensive. I am not tempted to try it as fed up with the number of supps gathering dust in my drawer that I can't tolerate.
Always "start low and go slow" when trying out new mitochondiral supplements. They can stimulate the sympathetic nervous system.
Every fatigued person is different.
Co10 and L-carnitine seems "too strong" (overstimulating) for me. NADH is good but strong. D-ribose works good. I would start at just 750mg of d-ribose to see how it affects you and take it up from there.
I have heard glowing reports about PQQ, some people say it worked better than anything else... some people say it keeps them up past their bedtime
Always "start low and go slow" when trying out new mitochondiral supplements. They can stimulate the sympathetic nervous system.
Every fatigued person is different.
Co10 and L-carnitine seems "too strong" (overstimulating) for me. NADH is good but strong. D-ribose works good. I would start at just 750mg of d-ribose to see how it affects you and take it up from there.
I have heard glowing reports about PQQ, some people say it worked better than anything else... some people say it keeps them up past their bedtime
I confess I find it extraordinarily difficult to know whether a supplement is really helping or not. I seem able to tolerate pretty much any of them, and none has so far made so immediate or noticeable difference that I can say with confidence "X has made a difference in my Y symptom." In addition, my state varies considerably on a day-to-day and week-to-week basis so that I seldom feel confident that any change is due to Z rather than the weather, barometric pressure, etc etc. So I tend to go by what looks like credible research.
Chris
Rich Van Konynenburg recommended me to support the Kreb´s cycle that probably was affected as I had an decreased methylation (confirmed by a Methylation Pathsways Panel).
Adenosylcobalamin, magnesium citrate, Q10 and l-carnitine fumarate on top of MeCbl, methylfolate and other co-factors to methylation. It helped. I also tried D-ribose but without effect.
I have noted some patients feel no difference with the Q10 recommended by Myhill. I bought it and it has never made any difference to me. However those same people have switched to Ubiquinol and found it effective. It is VERY expensive. I am not tempted to try it as fed up with the number of supps gathering dust in my drawer that I can't tolerate.
Here's a link to PQQ on Amazon.co.uk
Hi,
Where did you get the pathways test done? How much better are you now then...?