I notice a lot of similarities between MS and ME/CFS. Is it possible some ME/CFS folks might actually have MS? What are the more significant differences in symptoms? Is there a definitive test for MS? Any thoughts ....
MS is supposed to cause one-sided temporary paralysis, I believe, whereas ME patients often have bilateral problems (one leg might drag sooner than the other, but if keeping walking they may both drag.... or both arm weaken with use: in MS it may not be related to use).
The PEM of ME seems more severe than that of MS, and to my knowledge it does not include the kind of cardiopulmoary difficulties we seem to find and experience in ME.
Other than that it seems really similar. Most neurologists when meeting me not knowing my history want to test me for MS (if they know I have a CFS diagnosis, most typically they are looking for the fastest way to get me out the door with an excuse for why I do not actually need a neurologist despite multiple referrals in my file for 2-3 different things, occasionally from a panicking PCP... once of of the neuros looked scared once, too, before the brain scan).
My brain and neck scan is always stated as fine, meaning negative for MS and brain tumor (though they may find other things, but nothing diagnostic of anything in particular). I have had brain scans 3x. Never had a spinal tap, though.
I want to see your docs, @Inester7 . I can't keep a neuro, as I can't find one who can be civil to a no-diagnosis patient or a CFS-labeled patient, either one. Well I did have one, but insurance prevents me from seeing them. I can either have a decent neuro or a decent primary care doc, not both.

And the decent neuro comes with a very scary ER, tho I did meet one nice ER doc there.
Of course it's likely also possible to have both ME and MS.