Microcirculation APOE4 and LipoProtein(a)

Do you have high LP(a) and/or an APOE4 variant


  • Total voters
    4
  • Poll closed .
Messages
64
Likes
103
I'm not exactly sure where to place this thread but I would love to know if my thinking is relevant.
I am aware of the theory that microcirculation deficits may be responsible for ME/CFS or perhaps a downstream symptom.
For the brainfogged I want know how many people have high Lipoprotein A , aka LP(a) and or APOE4 genes. Both are associated with poor microcirculation.

apoe4
https://www.ahajournals.org/doi/10.1161/str.50.suppl_1.101

lp(a)
https://www.sciencedirect.com/science/article/abs/pii/S1567568809718124
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000800606


When I had my DNA done I was less than impressed to notice I was blessed with the rs3798220(C;T) , rs7770628(T;T) , rs10755578(C;C) , rs7767084(T;T)
I self funded a LP(a) test and found I had 1221 mg/L ( range 0-200)

I'm also APOE 3/4 (gs141) rs429358(C;T)+ rs7412(C;C)

I also have low butrylcholinesterase ( via rs1799807(A;G) AND the k variant rs1803274(A;G) which as far as I can understand impacts acetylcholine

I'm guessing researchers must have given more than a cursory glance at these but I havent seen any blatently labelled studies looking at me/cfs vs pop norm for these genes. Although I see people are interested https://solvecfs.org/hector-bonilla/

Next question, how do we increase microcirculation and decrease LP(a), Ive heard Niacin or asprin are effective in "some" cases for LP(a) and I saw this on mango extract https://nutraceuticalbusinessreview...d_glucose_metabolism_in_healthy_people/126180. I assume the likes of Nitric Oxide agents like Citruline /beta alanine/ arginine only work on larger arteries/veins
 

Ladycreole03

Senior Member
Messages
147
Likes
206

Ladycreole03

Senior Member
Messages
147
Likes
206
No, not really, Niacin "can" lower lp(a) but it doesn't work for everyone, it looks interesting for microcirculation but I suspect the effect is only for as long as the "flush".
Oh ok, like flush as in PEM?
Sorry, I'm new.