Gemini
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The gut bacteria, Enterococcus gallinarum, breaks through the gut wall and drives autoimmune disease in mice and humans that are genetically predisposed to autoimmunity researchers discovered: Science, March 9, 2018:
Antibiotic treatment with vancomycin or ampicillin alleviated pathological immune responses by suppressing growth of E.gallinarum in tissues and eliminating pathogenic autoantibodies and T cells. A vaccine specifically targeting E.gallinarum also appears effective.
Translocation of a gut pathobiont drives autoimmunity in mice and humans.
Manfredo Vieira S1, Hiltensperger M1, Kumar V2, Zegarra-Ruiz D1, Dehner C1, Khan N1, Costa FRC1, Tiniakou E1, Greiling T1, Ruff W1, Barbieri A3, Kriegel C1, Mehta SS4, Knight JR4, Jain D3, Goodman AL5, Kriegel MA6,2.
Author information
1 Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
2 Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
3 Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
4 Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.
5 Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale School of Medicine, New Haven, CT, USA.
6 Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. martin.kriegel@yale.edu.
https://www.ncbi.nlm.nih.gov/pubmed/?term=29590047
NIH highlights the discovery:
https://www.nih.gov/news-events/nih-research-matters/gut-microbe-drives-autoimmunity
Hopefully ME/CFS researchers Lipkin, Hanson, Carding, etc will take a look.
Antibiotic treatment with vancomycin or ampicillin alleviated pathological immune responses by suppressing growth of E.gallinarum in tissues and eliminating pathogenic autoantibodies and T cells. A vaccine specifically targeting E.gallinarum also appears effective.
Translocation of a gut pathobiont drives autoimmunity in mice and humans.
Manfredo Vieira S1, Hiltensperger M1, Kumar V2, Zegarra-Ruiz D1, Dehner C1, Khan N1, Costa FRC1, Tiniakou E1, Greiling T1, Ruff W1, Barbieri A3, Kriegel C1, Mehta SS4, Knight JR4, Jain D3, Goodman AL5, Kriegel MA6,2.
Author information
1 Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
2 Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
3 Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
4 Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.
5 Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale School of Medicine, New Haven, CT, USA.
6 Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. martin.kriegel@yale.edu.
https://www.ncbi.nlm.nih.gov/pubmed/?term=29590047
NIH highlights the discovery:
https://www.nih.gov/news-events/nih-research-matters/gut-microbe-drives-autoimmunity
Hopefully ME/CFS researchers Lipkin, Hanson, Carding, etc will take a look.