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I'm looking for advice on what to do regarding methylation supplementation. I see tons and tons of resources regarding it on here, but it honestly is all very overwhelming and I find myself uncertain.
I recently started taking 7.5mg l-Methylfolate along with 50mg B6, and 500mg Vitamin C (also 100mg 5-HTP 3x/day but I assume it doesn't relate to this much) as prescribed by my psychiatrist to address findings from a recent organic acids test. For the first few days on the methylfolate I experienced a noticeable increase in energy and general motivation but I've noticed the effects have subsided after less than a week of use. I imagine this means I am lacking in some other methylation requirement?
I know potassium is important and have (I think) experienced the effects of not having enough recently. I have been mindful to include potassium-rich foods in my diet and have not since experienced potassium deficiency.
I see B12 mentioned a lot, but it seems to be more-so something you should take to ensure you don't have masked B12 deficiency which I recognize is important but unless I'm mistaken doesn't entirely relate to my concerns at the moment.
I also found this https://me-pedia.org/wiki/Methylation_cycle_hypothesis#Freddd.27s_Protocol which seems to be a synopsis of Freddd's protocol which I've seen mentioned here a lot. I don't really feel comfortable following it completely since I have been prescribed the medications I'm currently on explicitly by my psychiatrist.
My current thinking is to add the "basic cofactors" section onto my current regimen one by one to try and find which one or multiple I may be additionally deficient in. I have no idea if this is a good idea though and would love some feedback from those with more experience and knowledge. Also, if anyone has any insight into what doses are recommended that would also be very helpful as it seems some of the supplements listed don't mentioned this.
I recently started taking 7.5mg l-Methylfolate along with 50mg B6, and 500mg Vitamin C (also 100mg 5-HTP 3x/day but I assume it doesn't relate to this much) as prescribed by my psychiatrist to address findings from a recent organic acids test. For the first few days on the methylfolate I experienced a noticeable increase in energy and general motivation but I've noticed the effects have subsided after less than a week of use. I imagine this means I am lacking in some other methylation requirement?
I know potassium is important and have (I think) experienced the effects of not having enough recently. I have been mindful to include potassium-rich foods in my diet and have not since experienced potassium deficiency.
I see B12 mentioned a lot, but it seems to be more-so something you should take to ensure you don't have masked B12 deficiency which I recognize is important but unless I'm mistaken doesn't entirely relate to my concerns at the moment.
I also found this https://me-pedia.org/wiki/Methylation_cycle_hypothesis#Freddd.27s_Protocol which seems to be a synopsis of Freddd's protocol which I've seen mentioned here a lot. I don't really feel comfortable following it completely since I have been prescribed the medications I'm currently on explicitly by my psychiatrist.
My current thinking is to add the "basic cofactors" section onto my current regimen one by one to try and find which one or multiple I may be additionally deficient in. I have no idea if this is a good idea though and would love some feedback from those with more experience and knowledge. Also, if anyone has any insight into what doses are recommended that would also be very helpful as it seems some of the supplements listed don't mentioned this.