Without RCT, how do you suggest that we gather evidence for the efficacy of a treatment?
It is prudent to read case studies, results of clinical trials, etc. But at best, ANYTHING is just a guess by the clinician.
If a drug company develops a new drug to treat disease X, and wants to test how effective that drug is, how are you going to do that without performing a RCT?
What replacement for RCTs would you suggest that works better?
It just seems to me that this is a false way to go about this.
The 21st Century Medicine White Paper I provided (did you happen to read it??) points out the fallacies of RCTs and suggests a different way of finding solutions for patients. That is to take a careful inventory of all the symptoms, the health history, and to do testing to identify treatable problems that work toward "normalizing" the body.
This can be a far more successful approach than the "cookbook medicine" approach common to conventional medicine, where we look for what pill treats what disease. As I've pointed out, you can give someone the "correct" pill for a certain disease, but they can be damaged due to their basket of genetics and environmental factors that make them different than the widget patients that the clinical trial was done on for that drug. (Or maybe they match up with patients in the clinical trial group who had the bad side effects.)
And other question: without drug treatment efficacy data from RCTs, how would functional doctors know which treatments to try?
- Immune system - IVIG, antivirals, antibiotics, LDN, zinc, vitamins A, C, and D, HBOT
- Dysautonomia - beta blockers, cholinergic substances (Huperzine A, neostigmine)
- Mast cells - cromolyn, ketotifen, ranitidine, quercetin, diphenhydramine, ondansetron
- Hormones - T3, T4, hydrocortisone, pregnenolone, DHEA, testosterone, estrogen, progesterone
- Blood - phlebotomies, bromelain
- Mitochondria - mitochondrial cocktail, phospholipids, oxidative and nitrosative stress reduction, BCAAs, FAD, NAD+, methylation support
- Metabolism - amino acids, B5, trace minerals
- Gut - probiotics, prebiotics, and mast cell meds above.
Conventional medicine treats multiple illnesses with multiple treatments. Nothing unusual about doing that. If you are a diabetic with high blood pressure and depression, you will be treated for all three illnesses at the same time.
And, while we wait for the scientists to tease out a perfect solution, this is the only path I know of to get better, and so far, though it's been tedious and expensive, it has been working for me, and I know of other ME/CFS patients who are quietly approaching this the same way with their doctors with a similar slow but positive path to success.
Many treatments have serious side effects, and going to a functional doctor (or ecological doctor as they are called in the UK) will not give you some indemnity against them. IVIG for example can sometimes cause serious side effects like meningitis; a functional doctor cannot protect you from these risks.