Depression from b2 means something odd. Irritability, anger, too much energy, anxiety... yeah sure but depression ? You need b2 for the krebs cycle. I don't know about a craze. What doses were having this effect?
Edit: since r5p is a rate limiting cofactor for the MTHFR enzyme could somehow increased methylation be causing depression?
Hi Dbkita,
Let's keep in mind that for those with the general CFS/FMS symptoms with anxiety things that turn up the Krebs cycle, specifically AdoCbl and LCF causes the irritability, anger, anxiety depression related to the rising and falling carnitine with depression at the far end and the anxiety and such have transformed into the depression. They are not there at the same time. In at least some people without the anxiety characteristic, when the deficiency starts hitting the brain, irritability increases in a GENERAL WAY. Then if AdoCbl is present in the CSF at too high a ratio to MeCbl,, irritability goes high in people not otherwise inclined in that directions. All sorts of things can give the feeling of depression. I found that while I had "depression" I didn't think in a depressed psychology way. I felt depressed and flat. Everything that helped energy also helped that depression; MeCbl, AdoCbl, LCF, SAM-e, zinc, l-Methylfolate were the big ones. I had in the first hour of the MeCbl, the "lights turned on". I also, in the middle of a conversation on the phone, had a change in neurological state and said "Oh, I could be happy now". That was a lifelong depression lifting off. It was mind blowing quick, less than 1 hour. After that it was incremental as I added other things.
We also know there is some relationship with serotonin but probably not as quickly as MeCbl can take effect though I don't know hopw long that would take.
So, B2 could fit in somewhere in all that. I have never had any noticeable effect of B1, B2 or B3 despite trying different ratios etc with individual items so I have no first hand experience in any of these.