In Martin Pall's theory, would tested N.O. levels be elevated or reduced?
Interestingly NO is usually low even though ONOO is high. I've done a lot of work to reduce ONOO, but only when I added Kuvan and/or Berkeley Life NO Booster did NO increase and symptoms improve.In Martin Pall's theory, would tested N.O. levels be elevated or reduced?
I'm no expert but I've seen it suggested that one of the primary potential drivers of ONOO is a failure to synthesize NO properly and this failure to synthesize NO properly drives the body to keep trying to produce it (NO) so that may be a reason why it could be seen to be in excess.
One part of the equation can be a BH4 (tetrahydrobiopterin) deficiency. BH4 is an essential cofactor for making nitric oxide so Kuvan that Learner1 benefits from can be addressing both a BH4 and NO conversion deficiency.
Interestingly, a subset of people with ME/CFS have found that supplying NO directly (with some form of NO donor) gives them significant symptom improvement, so doing this could be then be removing the driving force that makes ONOO.
Nitric oxide researcher Dave Whitlock disagrees with Pall's hypothesis and interestingly, he suggests getting NO from your diet is the best bang for your buck.Very interesting and may explain why my systemic levels of NO are low. My presumption is that eating foods high in nitrates bypasses this endogenous process and directly bumps up NO.
Kuvan is still an expensive prescription med and other BH4 supplements may be inferior products.Haven't heard of Kuvan - will research that
Nitric oxide researcher Dave Whitlock disagrees with Pall's hypothesis and interestingly, he suggests getting NO from your diet is the best bang for your buck.
Kuvan is still an expensive prescription med and other BH4 supplements may be inferior products.
How do you go about reducing ONOO?
It's only a hypothesis that NO can be the "x factor" to cause ME/CFS symptoms due to peroxynitite (ONOO) and no one has substantiated evidence of cause and effect from it. NO itself can also terminate some free radical processes and stop radical chain propagation reactions so that is presumably what is happening in the subset where NO supplementation is significantly beneficial.But if your boosting your NO, how are you keeping it from forming peroxynitrite ?
'treatment [....] with the combination of either urate with ascorbate or urate with cysteine completely prevented eNOS uncoupling caused by ONOO-. We conclude that the reducing and acidic properties of urate are important in effective scavenging of peroxynitrite and that cysteine and ascorbate markedly augment urate's antioxidant effect by reducing urate-derived radicals.'