ME/CFS: The Human Herpesviruses Are Back! (Ariza, 2021)

Pyrrhus

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back! (Ariza, 2021)
https://www.mdpi.com/2218-273X/11/2/185

Excerpt:
Ariza 2021 said:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) is a chronic multisystem illness of unconfirmed etiology. There are currently no biomarkers and/or signatures available to assist in the diagnosis of the syndrome and while numerous mechanisms have been hypothesized to explain the pathology of ME/CFS, the triggers and/or drivers remain unknown.

Initial studies suggested a potential role of the human herpesviruses especially Epstein-Barr virus (EBV) in the disease process but inconsistent and conflicting data led to the erroneous suggestion that these viruses had no role in the syndrome.

New studies using more advanced approaches have now demonstrated that specific proteins encoded by EBV could contribute to the immune and neurological abnormalities exhibited by a subgroup of patients with ME/CFS. Elucidating the role of these herpesvirus proteins in ME/CFS may lead to the identification of specific biomarkers and the development of novel therapeutics.
(spacing added for readability)
 

Pyrrhus

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Also by Maria Ariza:

Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset (Lerner et al., 2012)
https://forums.phoenixrising.me/thr...or-some-chronic-fatigue-syndrome-cases.20431/

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease (Williams et al., 2016)
https://forums.phoenixrising.me/thr...cations-for-human-diseases.48562/#post-799318

ME/CFS and Gulf War Illness patients exhibit increased humoral responses to the Herpesviruses-encoded dUTPase: Implications in disease pathophysiology. (Halpin et al., 2017)
https://forums.phoenixrising.me/thr...pesviruses-encoded-dutpase.50045/#post-841281

Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for ME/CFS (Williams et al., 2019)
https://forums.phoenixrising.me/thr...tory-mediators-implications-for-me-cfs.76123/
 

Pyrrhus

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And let's not forget the other current research efforts on herpesviruses:

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS (Schreiner, Harrer, Scheibenbogen, Lamer, Schlosser, Naviaux, and Prusty, 2020)
https://forums.phoenixrising.me/thr...agmentation-paper-pub-4-1-20-dr-prusty.79891/

Cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 infections in patients with ME/CFS (Shikova et al., 2020)
https://forums.phoenixrising.me/thr...und-in-large-me-cfs-study.80706/#post-2285664

Salivary DNA loads for human herpes viruses 6 and 7 are correlated with disease phenotype in ME/CFS (Lee et al. 2021)
https://forums.phoenixrising.me/thr...ase-phenotype-in-me-cfs-lee-et-al-2021.82801/